Chemotherapy mechanism

Matsumura, Y, and Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res., 1986, 46, 6387-6392. 

Olliaro, P. L. and Bloland, P. B. (2001) Clinical and public health implicationsof antimalarial drug resistance, in Antimalarial Chemotherapy Mechanisms of Action, Resistance, and New Directions in Drug Discovery (ed. P. J. Rosenthal), Humana Press, Totowa, NJ, pp. 65-83. 

Vial, H. J., and Calas, M. (2001). Inhibitors of phospholipid metabolism. In "Antimalarial Chemotherapy, Mechanisms of Action, Modes of Resistance and New Directions in Drug Development" (Rosenthal, ed.), pp. 347-365. Humana, Totowa, NJ. 

C. Resistance to Anticancer Drugs Drug resistance is a major problem in cancer chemotherapy. Mechanisms of resistance include the following. 

Rosenthal, P.J. (2001) Antimalarial Chemotherapy Mechanisms of Action, Resistance and New Directions in Drug Discovery, Humana Press. 

V. Malhotra, and M.C. Perry, Classical chemotherapy Mechanisms, toxicities and the therapeutic window. Cancer Biol Iher, 2 (4 Suppl 1), S2-4, 2003. 

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