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Anticancer agents drug resistance

Dou, Q. P. and Li, B. 1999. Proteasome inhibitors as potential novel anticancer agents. Drug Resist. Updat. 2 215-23. [Pg.209]

Methotrexate is used as an oral anticancer agent, but resistance may develop in tumour cells, and there are a number of unwanted side-effects. It has a high affinity for the mammalian form of dihydrofolate reductase and cannot be used as an antibacterial or antimalarial drug. After use at high doses in humans, the extent of depletion of folic acid may be such, that rescue with administration of folinic acid (a form of tetrahydrofolate) is necessary. [Pg.99]

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See also in sourсe #XX -- [ Pg.122 , Pg.123 , Pg.126 , Pg.131 ]



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Anticancer agents/drugs

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Anticancer drugs

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