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Transport mechanisms chemotherapy-resistant

Three classes of plant-derived drugs, the vinca alkaloids (vincristine, vinblastine, and vinorelbine), the epipodo-phyllotoxins (etoposide and teniposide and the tax-anes (paclitaxel and taxotere), are used in cancer chemotherapy. These classes differ in their structures and mechanisms of action but share the multidrug resistance mechanism, since they are all substrates for the multidrug transporter P-glycoprotein. [Pg.648]

The glutamate transporter-mediated increase of antitumor activity caused by theanine is a novel mechanism, and it is hoped that this action will lead to the discovery of a useful cancer chemotherapy for drug-sensitive, drug-resistant, and metastatic tumors. It was expected that this study will greatly contribute to clinical cancer chemotherapy in the future. ... [Pg.267]

See other pages where Transport mechanisms chemotherapy-resistant is mentioned: [Pg.179]    [Pg.426]    [Pg.343]    [Pg.540]    [Pg.622]    [Pg.201]    [Pg.284]    [Pg.286]    [Pg.26]    [Pg.154]    [Pg.617]    [Pg.390]    [Pg.3887]    [Pg.214]    [Pg.215]    [Pg.143]    [Pg.807]    [Pg.2290]    [Pg.154]    [Pg.100]    [Pg.114]    [Pg.3886]    [Pg.396]    [Pg.122]    [Pg.567]    [Pg.573]    [Pg.601]    [Pg.602]    [Pg.807]    [Pg.562]   


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Chemotherapy mechanisms

Resistance mechanisms

Transport mechanical

Transport mechanisms

Transporters mechanisms

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