Chemotherapy curcumin

Du B, Jiang L, Xia Q, Zhong L. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 1 23-28. 

Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ. 2002. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 62 3868-3875. 

Numerous studies have been published on the positive effects of turmeric, both in the prevention of cancer and in the recovery from chemotherapy and radiation treatment (Stoner and Mukhtar, 1995 Khafif, et al., 1998 Kawamori et al., 1999 Bush et al., 2001 Jung et al., 2005). In addition to its capacity to intervene in the initiation and growth of cancer cells and tumours, and to prevent their subsequent spread throughout the body by metastasis, curcumin increases cancer cells sensitivity to certain drugs commonly used to combat cancer, rendering chemotherapy more effective. 

As mentioned above, experimental dietary supplementation of curcumin was accompanied by a decrease in the activation of apoptosis by cyclophosphamide, as well as a decrease in JNK activation. These results demonstrate that curcumin can inhibit chemotherapy-induced apoptosis by inhibiting ROS generation and blocking JNK function, effects which would be counterproductive for breast cancer patients undergoing chemotherapy [131]. 

NCT01490996 A phase I/IIa study combining curcumin (Curcumin C3-Complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal... 

Sreekanth CN, Bava SV, Sreekumar E, Anto RJ (2011) Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene 30 3139-3152... 

Cabrespine-Faugeras A, Bayet-Robert M, Bay JO, CholletP, Barthomeuf C (2010) Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment. Nutr Cancer 62 148-153... 

Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB (2011) A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol... 

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