Chemotaxis receptors

Mowbray SL, Sandgren MO. 1998. Chemotaxis receptors a progress report on structure and function. J Struct Biol 124 257-75. 

Kim, S.-H. et al. (2002). Dynamic and clustering model of bacterial chemotaxis receptors Structural basis for signaling and high sensitivity. Proc. Natl. Acad. Sd. 99, 11611-11615. 

Fig. 4. Similarity/identity matrix generated for chemotaxis and non-chemotaxis GPCRs. Matrix was prepared for a representative set of 23 chemotaxis receptors, as well as for rhodopsin and the OiB-adrenergic receptor, using the program MATGAT (Gampanella et al, 2003). The lower half of the matrix indicates overall sequence similarity between each pair of receptors, while the upper half indicates overall sequence identity.

The chemotaxis receptors that do not bind chemokines also form dimers under certain conditions, but have not yet been found to undergo ligand-induced changes in oligomeric state. The G5a receptor is proposed to constitutively dimerize by association of respective TMIV domains, or possibly an interaction between TMl and TMII (Klco et at, 2003). For this receptor, no evidence yet exists to support ligand-induced dimerization... 

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