Chemotaxis Calcium

Benelli, R., Barbero, A., Ferrini, S., Scapini, P., Cassatella, M., Bussolino, F., Tacchetti, C., Noonan, D. M., and Albini, A. (2000). Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes Implications for Tat-mediated pathogenesis./. Infect. Dis. 182, 1643-1651. 

The anti-inflammatory activity of the NSAIDs is mediated chiefly through inhibition of biosynthesis of prostaglandins (Figure 36-2). Various NSAIDs have additional possible mechanisms of action, including inhibition of chemotaxis, down-regulation of interleukin-1 production, decreased production of free radicals and superoxide, and interference with calcium-mediated intracellular events. Aspirin irreversibly acetylates and blocks platelet cyclooxygenase, while most non-COX-selective NSAIDs are reversible inhibitors. 

Patel, M. K., Churn, G. F., Lymn, J. S., Austin, O. and Hughes, A. D., 2005, Effect of serum withdrawal on die contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells. Br J Pharmacol 145, 811—7. 

The physiological role of PHB/polyP complexes has not been established, but bacterial cells like eukaryotic cells maintain low internal Ca2+,101-103,112 and there is increasing evidence pointing to calcium involvement in a number of important cellular functions, such as chemotaxis, cell division, heat shock, pathogenicity, and differentiation.104-107 Systems for calcium export have been identified.108-109 Mechanisms for calcium entry are less well known. An L-type channel was reported in Bacillus subtilis,n0 lu and Jones et al. and Holland et al.103,112 recently demonstrated the presence of a putative Ca2+ influx channel in stationary phase E. coli,... 

Partida-Sanchez, S., Cockayne, D. A., Monard, S., Jacobson, E. L., Oppenheimer, N., Garvy, B., Kusser, K., Goodrich, S., Howard, M., Harmsen, A., Randall, T. D., and Lund, F. E. (2001). Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat. Med. 7, 1209-1216. 

MDC biological activity is assayed by calcium flux or chemotaxis using either primary cells or more commonly stable transfectants expressing CCR4 (Imai et al, 1998). 

Blocks calcium influx across mast ceU membranes Inhibits mast ceU degranulation Inhibits mast ceU degranulation Decreases chemotaxis... 

The effects of fosfomycin on several indices of neutrophil function have been studied in vitro (6). Phagocytosis was unaffected but there was enhanced bactericidal ability, increased intracellular calcium concentrations, raised extracellular reactive oxygen intermediate production, and reduced chemotaxis fosfomycin did not affect intracellular oxygen intermediate production or chemokinesis. 

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