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Chemokine molecular structure

Figure 1 Molecular structures of chemokine receptor therapeutics AMD3100/plerixafor and maraviroc. Figure 1 Molecular structures of chemokine receptor therapeutics AMD3100/plerixafor and maraviroc.
Fig. 2.5. Interactions of chemokines with heparin disaccharides. (A to C) Monomeric forms of chemokines are displayed as cartoons with residues found to interact with heparin colored red. (A) Monomer of crystal structure of CCL5 (RANTES) with heparin disaccharide I-S bound (red). (B) CXCL4 (PF4) with low-molecular-weight heparin (MW <9000d). (C) CXCL8 with heparin disaccharide I-S. (D) CXCL12 (SDF-la) with heparin disaccharide I-S. (E) CCL2, human IP-10, with conserved residues from murine IP-10 highlighted. Fig. 2.5. Interactions of chemokines with heparin disaccharides. (A to C) Monomeric forms of chemokines are displayed as cartoons with residues found to interact with heparin colored red. (A) Monomer of crystal structure of CCL5 (RANTES) with heparin disaccharide I-S bound (red). (B) CXCL4 (PF4) with low-molecular-weight heparin (MW <9000d). (C) CXCL8 with heparin disaccharide I-S. (D) CXCL12 (SDF-la) with heparin disaccharide I-S. (E) CCL2, human IP-10, with conserved residues from murine IP-10 highlighted.
Previously, the structure of MGP-1 /GGL2 was solved by NMR and subsequently by X-ray crystallography using the NMR structure as a starting model for molecular replacement (Lubkowski et al, 1997). As described in Section II.B, the solution structure revealed a dimer similar to dimerization motifs observed for other GC chemokines. In the case of the X-ray structure, two different crystal forms were isolated from the same droplet. One form contained a dimer similar to the solution structure (Fig. 2B), while the other form contained a tetramer as shown in Fig. 8. In the tetramer, there is a primary CC dimer interface that consists of the... [Pg.368]

Chemokines constitute a family of structurally related low molecular mass (8-11 kDa) proteins with diverse immune and neural functions. In addition to their well-established roles in the immune system, chemokines play a role in the migration, proliferation, differentiation, and survival of neural stem/pro-genitor cells. (Refer to the Cytokines and Chemokines Chapter 15.5 regarding chemokine and chemokine receptor classification and signaling pathways). [Pg.155]

Chemokines (CKs) are a group of low molecular weight cytokines that are identified on the basis of their ability to induce chemotaxis or chemokinesis in leukocytes (or in particular populations of leukocytes) in inflammation, the group is now divided into four subgroups on the basis of genetic, structural, and functional criteria. They function as regulators of the immune system and may also play roles in the circulatory and central nervous systems. ... [Pg.708]

The identification of three vCKBPs with no amino acid sequence similarity among themselves or to cellular receptors is providing us with novel protein structures capable of neutralizing chemokines in solution. Elucidation of the interaction of these vCKBPs with chemokines at the molecular level will provide some of the most interesting findings in this area of research. [Pg.23]


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Chemokines structures

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