Chemokine GPCR expression

CC Chemokine Receptor 2 (CCR2) is a member of the G protein-coupled receptor (GPCR) superfamily that serves as the receptor for monocyte chemoattractant proteins 1-4 (MCP-1 to -4), a group of pro-inflammatory chemotactic cytokines (chemokines). CCR2 is the primary chemokine receptor on inflammatory monocytes, and is also expressed on T-cells, dendritic cells, and endothelial cells. Upon ligand engagement, CCR2 mediates both cellular movement and activation. 

Chemokines exert their action through seven-transmembrane receptors, which are GPCRs (Fig. 4.2). Six CXC receptors, 10 CC receptors, and one receptor each for lymphotactin and fractalkine have been identified. Table 4.1 summarizes the human chemokine receptor family, their ligand specificity, and the cell types that predominantly express these receptors. The new nomenclature for chemokines is also included in the table (8). 

---