Chemokine biology macrophages

Secretion of cytokines by the activated macrophages, which increase fibroblast proliferation, angiogenesis factors, chemokines, in particular, monocyte chemoattractant protein (MCP-1), G-protein, nuclear factor /cB (NFkB), and other biologically active factors which regulate wound healing and iirflammatory processes. 

Czaplewski, L. G., McKeating, J., Craven, C. J., Higgins, L. D., Appay, V., Brown, A., et al. (1999). Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-l alpha, MIP-lbeta, and RANTES. Characterization of active disaggregated chemokine variants. The Journal of Biological Chemistry, 274(23), 16077—16084. 

Koopmann, W. and Krangel, M.S. (1997) Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-l-alpha. The Journal of Biological Chemistry, 272, 10103-10109. 

Nibbs, R.J., Wylie, S.M., Pragnell, I.B., and Graham, G.J. (1997) Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-lalpha receptors, CCR-1, CCR-3, and CCR-5. The Journal of Biological Chemistry, 272, 12495-12504. 

Figure 6.3 The roleofchemokines in the joints of RA patients. In the synovium macrophages, T cells, synoviocytes and chondrocytes produce various chemokines, such as CXCL8, CCL2 and CCL5. Cytokines such as ILip, TNFa and INFy stimulate these cells in the synovium. Chemokines in the inflamed joint recruit leukocytes into the joint. In addition, chemokines have also other biological activities. Chemokines stimulate fibroblast-like...

Greaves, D.R. et al. (2001) Hnked chromosome 16ql3 chemokines, macrophage-derived chemokine, fractaDdne, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 21. 923-929. 

Poltorak, A. N., Bazzoni, F., Smirnova, H, Alejos, E., Thompson, P., Luheshi, G., Rothwell, N., and Beutler, B. (1995) MIP-1 gamma molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo. J. Inflamm. 45(3), 207-219. Youn, B. S., Jang, I. K., Broxmeyer, H. E., Cooper, S., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Elick, T. A., Fraser, M. J., Jr., and Kwon, B. S. (1995) A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J. Immunol. 155(5), 2661-2667. 

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