Chemokine atopic dermatitis

Vestergaard C, Deleuran M, Gesser B, Gronhoj Larsen C. Expression of the T-helper 2-specific chemokine receptor CCR4 on CCRIO-positive lymphocytes in atopic dermatitis skin but not in psoriasis skin. Br J Dermatol 2003 149 457-463. 

Nickel RG, Casolaro V, Wahn U, et al. Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. J Immunol 2000 164(3) 1612-1616. 

Th-2 Cytokines Have Numerous Effects on Cutaneous Cells in Atopic Dermatitis In acute eczema, IL-4 and IL-13 induce a variety of local responses such as the induction of the adhesion molecules on endothelial cells, of chemokines or of Fc receptors on eosinophils [1]. Recent findings point to direct effects of IL-4 and... 

Giustizieri, M. L., Mascia, F., and Frezzolini, A. 2001. Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines. J Allergy Clin Immunol 107 871-877. 

Nakazato, J., Kishida, M., Kuroiwa, R., Fujiwara, J., Shimoda, M., and Shinomiya, N. 2008. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. Pediatr Allergy Immunol 19(7) 605-613 http //www.blackwell-synergy.eom/doi/abs/10.llll/j.1399-3038.2007.00692. 

Dianilino squarates, (V), prepared by Palovich (6) were effective in the treatment of diseases mediated by the chemokine, interleukin-8, and were used in the treating atopic dermatitis resulting in pruritus. 

Vestergaard, C., Yoneyama, H., Murai, M., Nakamura, K., Tamaki, K., Terashima, Y., Imai, T., Yoshie, O., Irimura, T., Mizutani, H., and Matsushima, K. (1999). Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 104, 1097-1105. 

Modulation of Chemokines by Staphylococcal Superantigen in Atopic Dermatitis... 

Association of Chemokines with an Atopic Dermatitis Phenotype... 

Staphylococcal Superantigens Induce Chemokine Production in Atopic Dermatitis Patients... 

Kaburagi Y, Shimada Y, Nagaoka T, Hasegawa M, Takehara K, Sato S Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-lalpha, MIP-lbeta, and eotaxin) in patients with atopic dermatitis. Arch Dermatol Res 2001 293 350-355. 

Gluck J, Rogala B Chemokine RANTES in atopic dermatitis. Arch Immunol Ther Exp (Warsz) 1999 47 367-372. 

Jahnz-Rozyk K, Targowski T, Paluchowska E, Owczarek W, Kucharczyk A Semm thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis. Allergy 2005 60 685-688. 

Hijnen D, De Bruin-Weller M, Oosting B, Lebre C, De Jong E, Bruijnzeel-Koomen C, Knol E Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell-attracting chemokine (CTACK) levels in allergic diseases TARC and CTACK are disease-specific markers for atopic dermatitis. J Allergy Clin Immunol 2004 113 334-340. 

Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii H, Asahina A, Onai N, Matsushima K, Tamaki K Thymus and activation-regulated chemokine in atopic dermatitis serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001 107 535-541. 

Morita E, HiragunT, Mihara S, Kaneko S, Matsuo H, Zhang Y, Dekio S Determination of thymus and activation-regulated chemokine (TARC)-contents in scales of atopic dermatitis. J Dermatol... 

Uchida T, Suto H, Ra C, Ogawa H, Kobata T, Okumura K Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis. Int Immunol 2002 14 1431-1438. 

Pivarcsi A, Gombert M, Dieu-Nosjean MC, Lauerma A, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A, Homey B CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J Immunol 2004 173 5810-5817. 

Nakayama T, Fujisawa R, Yamada H, Horikawa T, Kawasaki H, Hieshima K, Izawa D, Fujiie S, Tezuka T, Yoshie O Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal ker-atinocytes and its role in atopic dermatitis. Int Immunol 2001 13 95-103. 

Leung TF, Ma KC, Hon KL, Lam CW, Wan H, Li CY, Chan IH Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatr Allergy Immunol 2003 14 296-301. 

Shimada Y, Takehara K, Sato S Both Th2 and Thl chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis. J Dermatol Sci 2004 34 201-208. 

Hon KL, Leung TF, Ma KC, Li AM, Wong Y, Fok TF Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 2004 29 293-296. 

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