Chemokine analogs

Chemoattracts and activates neutrophils and basophils Chemokine analog of human herpes virus exhibits antagonistic activity toward several chemokine receptors Chemoattracts monocytes and resting T lymphocytes inhibits colony formation of bone marrow myeloid immature progenitors... 

Generating Chemokine Analogs with Enhanced Pharmacological Properties Using Phage Display... 

Table 3 A Summary of Chemokine Analogs That We Have Isolated Using the Methods Described in This Chapter N-Terminal Receptor Ligand Sequence Properties References ...

Bonsch, C., Munteanu, M., Rossitto-Borlat, I., Futstenberg, A., Hartley, O. (2015). Potent anti-HIV chemokine analogs direct post-endocytic sorting of CCR5. PLoS... 

Chemokine Analogs- Research Tools and Potential Therapeutics ... 

The most important clinical application of glucocorticoids and their semisynthetic analogs is their anti-inflammatory activity, discovered in 1949 by Hench and co-workers. The profound anti-inflammatory effects of glucocorticoids arise from the combined effects of these steroids on both the cellular and molecular mediators of inflammation these effects are separate from the metabolic effects described above and further indication of the widespread diversity of macromolecules to which steroids can bind. Glucocorticoids suppress inflammation at the cellular level by downregulating the concentration, distribution, and function of leukocytes (white blood cells) that profoundly influence inflammation and response to infection within the body (In this way, steroids help to mediate the overlap between the endocrine systems [chapter 5] and the immune systems [chapter 6]). Glucocorticoids also suppress inflammation at the molecule level by suppressing inflammatory cytokines, chemokines, and other molecular mediators of inflammation. 

Clark-Lewis, I., Dewald, B., Loetscher, M., Moser, B., and Baggiolini, M. (1994) Structural requirements for IL-8 function identified by design of analogs and CXC chemokine hybrids. J. Biol. Chem. 269,16,075-16,081. 

---