Chemistry CC

Another ABPP platform integrates click chemistry (CC), where an alkyne or azide group in the ABP acts as a latent attachment point for a reporter tag [34,35]. Replacing bulky reporter groups with an alkyne extends ABP design to include probes that function in live cells and... 

Dynamic combinatorial chemistry (DCC) is a rapidly emerging field that offers a possible alternative to the approach of traditional combinatorial chemistry (CC).32 Whereas CC involves the use of irreversible reactions to efficiently generate static libraries of related compounds, DCC relies on the use of reversible reactions to generate dynamic mixtures. The binding of one member of the dynamic library to a molecular trap (such as the binding site of a protein) is expected to perturb the library in favor of the formation of that member (Figure 29.1). 

The CC method has been designed first in the field of nuclear physics. This fact, however, had no consequences until recent years, since the numerical procedure has been judged by the community as untractable. Only because the quantum chemist Jiri Cizek accidentally looked up a nuclear physics journal, the idea diffused to quantum chemistry community and after some spectacular developments turned out to become the most successful in studying atoms and molecules. It turned out, however, that the idea went back to nuclear physics from quantum chemistry. The quantum chemistry CC technique has been applied to compute the energy levels for nucleons in several nuclei with much higher precision, than it was possible before. 

Combinatorial libraries Combinatorial chemistry (CC), in conjunction with massive screening methods, has generated considerable interest recently. CC allows for the rapid synthesis of vast libraries of small organic molecules, which are subsequently tested for therapeutic activity. The philosophy behind CC appears to oppose that of structure-based drug design. In the former, large enough numbers of molecules are synthesized and tested in the latter, a relatively small number of lead compounds are tested and optimized. 

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