Chemical sensitivity endocrine disrupters

The ultimate goals of the LRI are to fill the knowledge gap that is distorting public debate replace misinformation with scientific data increase the knowledge of the potential impacts that chemicals may have on the health of human and wildlife populations and the environment, especially sensitive sub-populations replace decisions based on hazard alone with decisions based on risk address issues such as bio-monitoring, methodologies, endocrine disruption and provide alternatives to animal testing and persistent bioaccumulative toxic substances (PBTs). 

In order to identify compounds responsible for specific effects (i.e., endocrine disrupting or AhR hgands) observed in field studies, TIE or bioassay directed analysis approaches have increasingly been apphed over the last decade. In such approaches, sensitive bioassays are used to direct the fractionation of a sample extract until its complexity is sufficiently reduced to enable identification of those compoimds responsible for the activity measured in the bioassay. This strategy is based on differential extraction and fractionation methods and identification by chemical and biochemical analysis. TIE is a well-established technique having been originally developed by... 

As the years went by, 1 also learned many other things about toxicity problems associated with the chlorine industry. 1 have long since arrived at the conclusion that some of chlorine s toxic residuals are so odious that the industry should be fundamentally restructured with a much higher sensitivity being accorded to health and the environment than currently pervades our culture. And especially since we must reduce and eliminate endocrine disrupting chemicals... 

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