Cheilitis

Systemic treatment of 13-cis retinoic acid frequently leads to cheilitis and eye irritations (e.g., unspecific cornea inflammation). Also other symptoms such as headache, pruritus, alopecia, pains of joints and bone, and exostosis formation have been reported. Notably, an increase of very low density lipoproteins and triglycerides accompanied by a decrease of the high density lipoproteins has been reported in 10-20% of treated patients. Transiently, liver function markers can increase during oral retinoid therapy. Etretinate causes the side effects of 13-cis retinoid acid at lower doses. In addition to this, generalized edema and centrilobulary toxic liver cell necrosis have been observed. 

Actinic keratosis of the lip is known as actinic cheilitis it usually affects the lower lip, which is more sun-exposed. 

Angular cheilitis presents with small cracking lesions, erythema, and soreness at the corners of the mouth associated with vitamin and iron deficiency... 

Hypersensitivity to any component monotherapy in primary bacterial infections such as impetigo, paronychia, erysipelas, cellulitis, angular cheilitis, erythrasma (clobetasol), treatment of rosacea, perioral dermatitis, or acne use on the face, groin, or axilla (very high or high potency agents) ophthalmic use. 

Skin complaints, particularly xerosis, conjunctivitis, and cheilitis. 

Riboflavin vitamin Bf) deficiency results in local seborrheic dermatitis that may be limited to the face and scrotum. Other symptoms of ariboflavinosis include angular stomatitis, cheilitis, and glossitis. Specific ocular... 

Bleeding skin, cheilitis, contact dermatitis, herpes simplex, lip swelling, nausea, numbness, rosacea, and weakness have been reported. 

Irritation, skin pain. Assuring, localized edema, skin discoloration, rash, desquamation, contact dermatitis, skin inflammation, bleeding, dry skin, hypertriglyceridemia, peripheral edema, acne vulgaris, cheilitis... 

Glucagon infusions in the treatment of tumor-induced hypoglycemia can cause adverse effects comparable to the effects of a glucagonoma (hyperglycemia, necrolytic migratory erythema, weight loss, anemia, angular cheilitis, and venous thrombosis), as reported in three patients (10). 

A 38-year-old woman developed erythematous dermatitis, in a skin biopsy consistent with necrolytic migratory erythema, and angular cheilitis, which disappeared after withdrawal of glucagon infusion after 2 months. 

After 5 months of glucagon treatment a 38-year-old man developed an erythematous scaly rash and angular cheilitis, which subsided dramatically after withdrawal of the glucagon. 

Inflammation of the mucous membranes of the lip (cheilitis), the mouth (stomatitis), the eye (conjunctivitis), and skin capillaries (erythema)... 

Strauss, R.M. and Orton, D.I., Allergic contact cheilitis in the United Kingdom a retrospective study, Am. J. Contact Dermatitis, 14, 75, 2003. 

Leow, Y.H., Tan, S.H., andNg, S.R., Pigmented contact cheilitis from ricinoleic acid in lipstick, Contact Dermatitis, 49, 48, 2003. 

Gum, J.D., Allergic contact cheilitis from diisostearyl malate in lipstick, Contact Dermatitis, 44, 375, 2001. 

Asai, M., Kawada, A., Aragane, Y., and Tezuka, T., Allergic contact cheilitis due to glyceryl monoisostearate monomyristate in a lipstick, Contact Dermatitis, 45, 173, 2001. 

Adachi, A. and Yamada, Y., Allergic contact cheilitis due to isopalmityl diglyceryl sebacate and pentaerythritol rosinate in the lipsticks, Environ. Dermatol. Jpn), 10, 70, 2003. 

Isotretinoin Fatigue headache nausea and vomiting pruricis Teratogenic cheilitis xerostomia rash conjunctivitis and eye irritation anorexia hypertriglyceridaemia pseudotumour cerebri... 

Pre-existing vesicular edematous cheilitis (probably due to contact allergy to the protecting lip salve) was aggravated after application of Zovirax cream (26). Patch tests to the lip salve were positive, but in addition there were positive photopatch tests to Zovirax cream, but not to its separate constituents. 

Two other patients with cheilitis due to contact allergy to a lipstick reacted positively to glyceryl hydrogenated rosinate, an ester gum, and the main component of the rosinate, glyceryl abietate (both patchtested at 20% in petrolatum) (9). 

---