Meat, charcoal-broiled

CYP1A2 is known to play a significant role in the metabolism of aromatic amines, estradiol, and other drugs. Furthermore, it is known that CYP1A2 is induced by cigarette smoke and charcoal-broiled meat. 

Environmental chemicals and pollutants are also capable of inducing P450 enzymes. As previously noted, exposure to benzo[a]pyrene and other polycyclic aromatic hydrocarbons, which are present in tobacco smoke, charcoal-broiled meat, and other organic pyrolysis products, is known to induce CYP1A enzymes and to alter the rates of drug metabolism. Other environmental chemicals known to induce specific P450s include the polychlorinated biphenyls (PCBs), which were once used widely in industry as insulating materials and plasticizers, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin, TCDD), a trace byproduct of the chemical synthesis of the defoliant 2,4,5-T (see Chapter 56). 

CYP1A2 Caffeine Theophylline Tobacco Charcoal-broiled meat Fluvoxamine (Yes)" Caffeine... 

Lijinsky, W. and Shubik, P. (1964) Benzo(a)pyrene and other polynuclear hydrocarbons in charcoal-broiled meat. Science 145, 53-55. 

Benzo[a]pyrene is one of the most carcinogenic of the aromatic hydrocarbons. This hydrocarbon is formed whenever an organic compound undergoes incomplete combustion. For example, benzo[a]pyrene is found in cigarette smoke, automobile exhaust, and charcoal-broiled meat. Several... 

EXPOSURE ROUTES high exposure from smoking cigarettes and the ingestion of certain foods (e.g. smoked and charcoal broiled meats and fish) industrial and municipal discharges inhalation of contaminated air consumption of contaminated food and water... 

EXPOSURE ROUTES gasoline and diesel exhaust cigarette smoke coal tar inhalation of contaminated air skin contact ingestion of contaminated food and foods like smoked or charcoal broiled meats and fish... 

Features Present in environment due to incomplete combustion of organic matter (e.g., in coal tar volatiles, tobacco smoke, exhaust emissions, charcoal broiled meat smoke, edible oils, surf, waters, lake sediments)... 

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