Chamomilla Flavonoids

Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000 59 1387-1394. 

Normal-phase TLC using a silica stationary phase was employed for the optimization of the separation of flavonoid content of Matricariae flos (Chamomilla recutita L. Rauschert). Air-dried and powdered plant material was extracted by refluxing for 10 min with methanol. The suspension was filtered, evaporated and the residue was redissolved in methanol. The mobile phases included in the experiments were 1 = ethyl acetate-methylethylketone-formic acid-water (50 30 10 10, v/v) 2 = ethyl acetate-methanol-water (75 15 10 v/v) 3 = ethyl acetate-formic acid-water (80 10 10, v/v) 4 = ethyl acetate-formic acid-water (100 20 30, v/v) 5 = ethyl acetate-formic acid-acetic acid-water (100 11 11 27, v/v) 6 = n-butanol-acetic acid-water (66 17 17, v/v) 7 = ethyl acetate-methanol-formic acid-water (75 10 5 10, v/v) 8 = ethyl acetate-acetic acid-water (80 10 10, v/v). Development was carried out in the linear ascending mode at... 

Babenko NA, Shakhova EG. 2006. Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats. Exp Gerontol 41 32-39. 

Matricaria chamomilla L. -camomila Nervous disturbances Flower (infusion) Afro-Brazilians (Northeast Brazil) [45,46] Flavonoids [104,105] essential oil [106] acylglycerols, linoleic and linolenic acids [107] coumarins [108,109] sesquiterpene lactone [110] inhibits both development of morphine dependence and expression of abstinence syndrome [255,256] anxiolytic effect [257] sedative as well as spasmolytic effects [258]... 

The species Chamomilla recutita (chamomile) is rich in phenolic compounds, cumarines, phenolic acids and, especially, flavonoids such as p-D-glycosyl-7-apigenine and their acetylated derivatives, luteolin glucosides, quercetin heterosides and their methylated genines [90]. Apart from its known antispasmolytic activity, it also protects against ulceration mediated by indomethacin, stress and absolute alcohol. 

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