Cervical cancer spectroscopy

Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy, MAGMA), Magn. Re-son. Mater. Phys., Biol. Med. 16, 174-181. 

T. Morimoto, T. Qbata, T. Qhno, Y. Suzuki, H. Ikehira, T. Suhara, S. Furukawa, H. Tsujii and T. Nakano, Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using a transvaginal surface coil. Magn. Reson. Med. Sci., 2005, 4,197-201. 

History of FTIR spectroscopy applied to cervical cancer diagnosis... 

Wood, B. R., Quinn, M. A., Burden, F. R. and McNaughton, D. (1996) An investigation into FTIR spectroscopy as a biodiagnostic tool for cervical cancer. Biospectroscopy 2, 143-53. 

Workers at Johns Hopkins University, under the tutelage of Chris Brown, worked on screening PAP smears using NIR spectroscopy [229]. Healthy patients, patients with abnormal cells, and patients with cervical cancer were screened. Using discriminant analysis and principal component analysis, the samples were grouped and employed to examine further samples. It was seen that malignant and healthy tissues were distinctly different, while abnormal tissues carried spectral features from both sets. New developments for the detection of cervical cancer by NIR have been published by Yang et al. [230]. The possibility to detect endometrial cancer was also tested [231]. 

The results show the ability of Raman spectroscopy to classify cervical cancer and pre-cancer with high sensitivity and specificity. These classifications are based on biochemical changes known to accompany cervical cancer such as loss of differentiation and increased proliferation. This study shows the capability of Raman microspectroscopy to investigate not only the tissue but also the cells within the tissue, as it is known that a tumour can contain a heterogeneous population of cells. 

S. Feng, D. Lin, J. Lin, B. Li, Z. Huang, G. Chen, W. Zhang, L. Wang, J. Pan, R. Chen, H. Zeng, Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer. Analyst 138, 3967 (2013)... 

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