Cerebrovascular disorders ischemic

J6. Joviiic, A., Ivanisevic, V., and Ivanovic, I., Lipoprotein(a) in patients with carotid atherosclerosis and ischemic cerebrovascular disorders. Atherosclerosis (Shannon, Irel.) 98, 59-65 (1993). 

Several diseases are known which are associated with BBB disruption. These include brain tumor metastases epilepsy and the more severe condition of status epilepticus cerebrovascular disorders autoimmune diseases such as multiple sclerosis acute cerebral infarcts meningeal carcinomatosis and ischemic white matter lesions. " Several genetic polymorphisms are known which increase the susceptibility to BBB disruption. These include polymorphisms in glutathione transferase, important for protection against oxidative stress, and malfunctioning variants of serum BChE (e.g., atypical BC/ffi). In particular, such mutations increase the risk of BBB disruption that is involved with exposure to anticholinesterases or to lead sulfate batteries, with subsequent increased risk for Parkinson s disease. ... 

The development of these chronic. Western-type diseases is associated with an excessive formation and function of eicosanoids derived from n-6 fatty acids. As balance can be restored to eicosanoid biosynthesis by dietary n-3 fatty acids, an effective strategy to diminish cardio-cerebrovascular mortality (in addition to several other serious disorders) may be to decrease the intake of n-6 fatty acids and replace them with n-3 fatty acids (116). Such a strategy is supported by studies that show an increased incidence of cardiovascular diseases, specifically ischemic heart disease, in Japanese whose diet has increasingly become more Westernized (113, 117). 

Cerebrovascular thrombosis (CVT) occurs in over 1.5 million individuals yearly in the USA of these 66% suffer death or severe permanent paralysis. In those suffering CVT, including transient cerebral ischemic attacks (TIA s), small stroke syndrome (SSS) and Sank thrombotic stroke, at least 30% harbor a blood coagulation protein or platelet defect causing thrombosis. Like the disorders discussed above, the need for defining the presence or absence and type of defect is of obvious importance. 

Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions, such as coronary heart disease (CHD), ischemic cerebrovascular disease, and peripheral vascular disease. These conditions account for most morbidity and mortality among middle-aged and older adults. DysUpidemias, including hyperhpidemia (hypercholesterolemia) and low levels of high-density-hpoprotein cholesterol (HDL-C), are major causes of increased atherogenesis both genetic disorders and lifestyle (sedentary behavior and diets high in calories, saturated fat, and cholesterol) contribute to the dysUpidemias seen in developed countries. 

These disorders include hypertensive disease, ischemic heart disease, other forms of heart disease, and cerebrovascular disease. As with cancer, the specific contribution of occupational factors to the causation of CVD has been debated, but there is agreement that some workplace factors contribute to or cause CVD (see Smith and Sainfort 1990 for a detailed discussion of psychosocial factors and their contribution). Four main occupational sources of CVD causation are agents that affect cardiopulmonary capacity, chemicals, noise, and psychosocial stress. 

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