Cerebrospinal fluid bilirubin

Stempfel, R., Serum and cerebrospinal fluid bilirubin in hemolytic disease of newborn. Acta Pediat. 44, 502 (1955). 

Stempfel, R., and Zetterstrom, R., Cerebrospinal fluid bilirubin in the neonatal period with special reference to the development of kemicterus. Acta Paediat. 43, 582-586 (1954). 

Serum and Cerebrospinal Fluid Bilirubin and Protein Levels in Relation TO Tocopherol Administration... 

Both free and conjugated bilirubin have been detected in the cerebrospinal fluid (CSF) using diazotization techniques. The amounts are... 

A3. Amatuzio, D. S., Weber, L. J., and Nesbitt, S., Bilirubin and protein in the cerebrospinal fluid of jaundiced patients with severe liver disease with and without hepatic coma. /. Lab. Clin. Med. 41, 615-618 (1953). 

Bilirubin - an apolar, water-insoluble lipophile substance - is potentially toxic. It is bound to serum albumin and transported to the sinusoidal membrane of the liver cell as a bilirubin-albumin complex, (s. fig. 3.1) The binding capacity of albumin is exceeded only at a serum bilirubin concentration of >4—5 mg/dl. In the case of decreased albumin binding (e. g. in acidosis) or oversaturated binding capacity, there is a danger of toxic cell damage due to the diffusion of unbound bilirubin into the cells (in some cases accompanied by kernicterus). Neonates and premature babies are at particular risk because of their immature blood-cerebrospinal fluid barrier. Albumin-bound bilirubin can function as an antioxidant to intercept free radicals and/or O2 radicals. (93) (s. tab. 3.25)... 

---