Cerebellum glutamatergic neurons

The hippocampus is characterized by a series of glutamatergic neurons, which can create rhythms of electrical activity necessary for the generation of memory traces in the brain. The cerebellum, a region dedicated to the temporal processing of motor and cognitive in-... 

The stargazer mutant mouse is ataxic and epileptic. It lacks functional AMPA receptors (Fig. 30-1), which apparently are not delivered successfully to the synapses in the cerebellum in which they function.380 386 Mutation of a transmembrane protein stargazin, which may interact with the AMP receptor, causes the symptoms.457 458 NMDA receptors (Fig. 30-20) are involved in synapse formation in the brain. Filopodial extensions on dendrites, triggered by electrical activity, are essential for synapse formation,459 which occurs rapidly.4593 Activation of NMDA receptors is apparently also necessary.379 460 Without this stimulation the excitatory glutamatergic neurons of the developing brain undergo apoptosis. 

Llansola M, Minana MD, Montoliu C, Saez R, CoRBALAN R, Manzo L and Felipo V (1999) Prenatal exposure to aluminum reduces expression of neuronal nitric oxide synthase and of soluble guanylate cyclase and impairs glutamatergic neurotransmission in rat cerebellum. J Neurochem 73 712-718. 

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