Cerebellum calcium release

Kreitzer AC, Malenka RC (2005) Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum. J Neurosci 25(45) 10537—45 Kreitzer AC, Regehr WG (2001) Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto purkinje cells. Neuron 29 717-27 Kreitzer AC, Carter AG, Regehr WG (2002) Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron 34 787-96... 

Aluminum in micromolar concentrations was found to inhibit calcium pumping in endoplasmic reticulum. The Ca2+ ATPase activity of rat brain and cerebellum was remarkably reduced and mitochondria showed increased Ca2+ release in the presence of exactly estimated 50 pmol L-1 Al3+ [67]. Aluminum was found to be an important disrupter of intracellular calcium homeostasis, interfering also with the mitochondrial Ca2+ pump, as well as activating an Na+-K+ ATPase - the antiport mechanism of ion exchange in the plasma membrane, which regulates the Ca2+-Na+ antiporter exchange [67]. 

Another set of proteins that bind to the SNARE complex are complexins I and II. These small proteins ( 15 kD) are highly enriched in brain, particularly at synapses. Complexins are implicated in calcium-mediated neurotransmitter release, where their role is thought to be in the stabilization of the SNARE complex (Marz and Hanson, 2002). Both complexins are also implicated in schizophrenia, as levels of complexin I and II mRNA are decreased in the temporal lobe and hippocampus (Eastwood and Harrison, 1998), while levels of complexin II mRNA are decreased in the cerebellum (Eastwood et al., 2001b). This is consistent with the finding that complexin I protein is decreased in the prefrontal cortex (Sawada et al., 2002), and both complexins I and II protein are decreased in the hippocampus (Sawada et al., 2005) of... 

Pearce B R., Currie D N, Beale R., and Dutton G R. (1981) Potassium-stimulated, calcium-dependent release of [ H] GABA from neuron-and gha-ennched cultures of cells dissociated from rat cerebellum Brain Res 206, 485-489... 

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