Cerebellar nuclei globose nucleus

The cerebellum is responsible for the coordination of movement, and is composed of a cortex of gray matter, internal white matter, and three pairs of deep nuclei fastigial nucleus (FN), the interposed and globose nucleus, and dentate nucleus. The deep cerebellar nuclei and the vestibular nuclei transmit the entire output of the cerebellum. Output of the cerebellar cortex is carried through Purkinje cells. Purkinje cells send their axons to the deep cerebellar nuclei and have an inhibitory effect on these nuclei. The cerebellum is involved with both eye and head movements, and both tonic and phasic activities are reported in the cerebellum. The cerebellum is not directly responsible for the initiation or execution of a saccade, but contributes to saccade precision. Sites within the cerebellum important for the control of eye movements include the oculomotor vermis, FN and the flocculus. Consistent with the operation of the cerebellum for other movement activities, the cerebellum is postulated here to act as the coordinator for a saccade, and act as a precise gating mechanism. 

This chapter correlates emotions and attachment behavior in autism with the disturbed neuroanatomy found in the brains of these individuals. Neuropathological postmortem studies have consistently found abnormalities in the limbic system and the cerebellum of autistic individuals. Abnormal limbic structures include the amygdala, hippocampus, septal nucleus, and anterior cingulate cortex. In the cerebellum, abnormalities have been found in the cerebellar hemispheres and in the fastigial, emboliform, and globose nuclei. 

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