Ceramides functions

Mencarelli C, Martinez-Martinez R Ceramide function in the brain when a slight tilt is enough. Cell Mol Life Sci. 2013 70(2) 181-203. 

Raith and Neubert [57] have developed a method for the profihng of human stratum comeum ceramides. The method enables the investigation of the role of ceramides in maintaining the barrier function of stratum comeum. TLC using automated multiple development was modified for semipreparative purposes. The fractionation of complex lipid extracts using this method ensured specific, sensitive, and... 

Rao, R. P, Yuan, C., Allegood, J. C. et al. 2007. Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Proc. Natl. Acad. Sci. U.S.A., 104(27) 11364—11369. 

K. Matsuoka, M. Terabatake, Y. Esumi, D. Terunuma, and H. Kuzuhara, Synthetic assembly of trisaccharide moieties of globotriaosyl ceramide using carbosilane dendrimers as cores. A new type of functional glyco-material, Tetrahedron Lett., 40 (1999) 7839-7842. 

Mutant or knockout mice defective in specific enzymes involved in lipid synthesis have provided powerful tools for genetic analysis of lipid function in the nervous system. For example, disruption of the genes for ceramide galactosyl transferase or galactosyl ceramide sulfotransferase,... 

Buccliero, R. and Futerman, H. The roles of ceramide and complex sphingolipids in neuronal cell function. Pharm. Res. 47 409-419, 2003. 

Fully functionalized ceramide Azide used as precursor... 

The stratum corneum consists of separated, nonviable, cornified, almost nonpermeable corneocytes embedded into a continuous lipid bilayer made of various classes of lipids, for example, ceramides, cholesterol, cholesterol esters, free fatty acids, and triglycerides [6], Structurally, this epidermis layer is best described by the so-called brick-and-mortar model [7], The stratum corneum is crucial for the barrier function of the skin, controlling percutaneous absorption of dermally applied substances and regulating fluid homeostasis. The thickness of the stratum corneum is usually 10-25 /an, with exceptions at the soles of the feet and the palms, and swells several-fold when hydrated. All components of the stratum corneum originate from the basal layer of the epidermis, the stratum germinativum. 

Hannun, Y.A., 1996, Functions of ceramide in coordinating cellular responses to stress. Science nA. 1855-1859. 

Figure I. Displayed are the structures of sphingomyelin and ceramide. Sphingomyelinases function as phospholipases C to hydrolyze sphingomyelin.

The function of ASM-released ceramide is not restricted to receptor-initiated signaling, but has been also demonstrated to play a pivotal role in... 

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