Ceramide galactosyl-3 sulfate

Sulfatide (ceramide galactosyl-3 -sulfate) is present in many tissues. Accumulation of sulfatide and related compounds resulting from the storage disorder metachromatic leukodystrophy was followed by a normal-phase separation on a silica column (A = 229 nm) using a 16-min 99/1 - 80/20 hexane/dioxane gradient [718]. Good resolution between sulfated and six related compounds was obtained and the last analyte of interest eluted in <10 min. 

Arylsuifatase A (EC 3.1.6.8). Accumulation of galactosyl sulfate ceramide and lactosyl sulfate ceramide in kidneys and gall bladder, and galactosyl sulfate ceramide alone in brain white matter and peripheral nerve sheaths. Cerebral degeneration and motor disturbances. Death 5-10 years after onset, or at 3-7 years of age (infantile form). 

Glycolipids are important constituents of the plasma membranes, of the endoplasmic reticulum, and of chloroplasts. The cerebrosides and their sulfate esters, the sulfatides, are especially abundant in myelin. In plant membranes, the predominant lipids are the galactosyl diglycerides.29 74 The previously described ether phospholipids (archaebacteria), ceramide arnino-ethylphosphonate (invertebrates), and sulfolipid (chloroplasts) are also important membrane components. 

A partial synthesis of cerebroside sulfate [ sulfatide, the glycoside of ceramide with galactose 3-sulfate, (90)] was achieved [90] by acylating the sphingosine galactosyl 3-sulfate (89) (obtained by basic hydrolysis of natural sulfatide) with palmitoyl chloride or D-2-acetoxypalmitoyl chloride (and subsequent basic hydrolysis of the... 

---