Lactosyl ceramide sulfate

The galactose bears a 3-sulfate group in cerebroside sulfatides, e.g., in lactosyl ceramide sulfate ... 

Another group of the acidic glycosphingolipids are the sulfoglycosphingolipids (formerly called sulfatides ). This field is comprehensively reviewed in [6]. Most abundant in mammalian tissues is 3-0-sulfogalactosylceramide (O Fig. IS) which occurs, e. g., in human kidney, rat lung, and in the human central and peripheral nervous system. Also, lactosyl -sulfate ceramide is found in mammalian tissues, e. g., in human kidney and liver. Higher glycosylated molecules are present, e. g., in human kidney, and in the rat and human central and peripheral nervous systems. 

Arylsuifatase A (EC 3.1.6.8). Accumulation of galactosyl sulfate ceramide and lactosyl sulfate ceramide in kidneys and gall bladder, and galactosyl sulfate ceramide alone in brain white matter and peripheral nerve sheaths. Cerebral degeneration and motor disturbances. Death 5-10 years after onset, or at 3-7 years of age (infantile form). 

Acetobromolactose has been used to make 2-O-p-Iactosyl glycerol, 1,2-di-O- -lactosyl-(R,S)-glycerol and the trisubstituted glycerol. Lactose has also been used to make the ceramide derivatives (85, a d), the first being spectroscopically almost identical to natural acanthalactoside Several sulfates of lactose are referred to in Chapter 7. 

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