Ceramide Analog PDMP

Fig. 4. A synthetic ceramide analog, L-PDMP, facilitates functional synapse formation. (A) The dose-dependent effects of PDMP isomers on the frequencies of synchronous oscillations of the cortical neurons. The cells were treated with PDMP isomers at the concentrations of 5 and 40 mM for 8 days (1-9 DIV). (B) Time dependency of the stimulatory effect of L-PDMP on functional synapse formation. The cells were treated with 20 mM L-PDMP for 1 (8-9 DIV), 3 (6-9 DIV), 6 (3-9 DIV), and 8 days (1-9 DIV). P < 0.01, significant difference from the values in the absence of PDMP at each point.

Inokuchi, J., Mizutani, A., Jimbo, M., Usuki, S., Yamagishi, K., Mochizuki, H., Muramoto, K., Kobayashi, K., Kuroda, Y., Iwasaki, K., Ohgami, Y., and Fujiwara, M. (1997). Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (1-PDMP). Biochem. Biophys. Res. Commun. 237, 595—600. 

Schneider, J. S., Bradbury, K. A., Anada, Y., Inokuchi, J., and Anderson, D. W. (2006). The synthetic ceramide analog l-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism. Brain Res. 1099, 199-205. 

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