Cephalothin interaction

Cephalosporins such as cephalothin and cephaloridine interact with both the anionic (p-aminohippurate, PAH) and cationic (tetraethylammonium, TEA or N-methybiicotinamid, NMN) transport systems [31, 67, 85]. p-lactams have been shown to be secreted by the S2 segment of the proximal tubule via the PAH transport system [85]. Cephalothin inhibited the transport of PAH in rabbit basolateral and in brush border membrane vesicles [84] while cephaloridine inhibited the transport of PAH and TEA and in rat renal cortical slices [26, 77] and of PAH [77, 84] or NMN [84] in rat brush border membrane vesicles (BBMV). 

Clinically important, potentially hazardous interactions with aminoglycosides, cephalothin, teicoplanin... 

Clinically important, potentially hazardous interactions with adefovir, aldesleukin, aminoglycosides, atracurium, bumetanide, carbenicillin, cephalexin, cephalothin, doxacurium, ethacrynic acid, furosemide, methoxyflurane, non-polarizing muscle relaxants, pancuronium, pipecuronium, polypeptide antibiotics, rocuronium, succinylcholine, teicoplanin, torsemide, tubocurarine, vecuronium... 

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