Central nervous system regeneration

Caroni P, Savio T, Schwab ME (1988) Central nervous system regeneration Oligodendrocytes and myelin as non-permissive substrates for neurite growth. Prog Brain Res 78 363-370. 

Ferraro GB, Alabed YZ, Fournier AE (2004) Molecular targets to promote central nervous system regeneration. Curr Neurovasc Res 1 61-75. 

Fry El (2001) Central nervous system regeneration Mission impossible Clin Exp Pharmacol Physiol 28 253-258. 

Fry, E.J., Central nervous system regeneration mission impossible Clin. Exp. Pharmacol. Physiol. 28,253-258,2001. 

Antiepileptics are used in neuropathic pain resulting from lesions to the peripheral (e.g., diabetes, heipes) or central nervous system (e.g., stroke). Such syndromes have been attributed to ectopic activity in sensitized nociceptors from regenerating nerve sprouts, recruitment of previously silent nociceptors, and/or spontaneous neuronal activity. This may result in sensitization... 

Another area where polymers are making a significant difference in nerve regeneration is the use of polymers to encapsulate and release trophic factors, or encapsulate cells that release nerve growth factor or other agents that enhance the regeneration process. This chapter details the advances in the use of polymeric biomaterials that have been explored for nerve regeneration in the peripheral and central nervous systems. 

Tatagiba, M., Brosamle, C., and Schwab, M.E. 1997. Regeneration of injured axons in the adult mammalian central nervous system. Neurosurgery 40(3), 541-546. 

Nogo-A is a potent inhibitor of neurite growth and blocks axonal regeneration in the central nervous system. Early in vitro experiments showed that neurite outgrowth was impeded across a culture dish coated with CNS myelin whereas neurites would actively grow on a... 

While atropine blocks the muscarinic effects, 2-PAM regenerates cholinesterase enzymes in sympathetic, parasympathetic, and central nervous system sites. 

Central nervous system effects predominate in acute exposures at massive doses, whereas peripheral neuropathy is more common with lower doses.After cessation of exposure to acrylamide, most cases recover, although the course of improvement can extend over months to years and depends on the severity of exposure. Because peripheral neurons can regenerate and central axons cannot, severely affected individuals may still experience residual ataxia, distal weakness, reflex loss, or sensory disturbance. 

Okano, H., Sakaguchi, M., Ohki, K., Suzuki, N., Sawamoto, K. (2007) Regeneration of the central nervous system using endogenous repair mechanisms. J Neurochem 102, 1459-... 

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