Cellular physiology stress models

Translation of cellular stress models needs to be linked to the cellular physiology that occurs in single cells. This will ensure that the probability of events in terms of modeling will play a prime role. These events include the amount of transcripts and, therefore, molecules of certain transcription factors regulating the onset of stress response routes (Brul et al., 2002a). 

Mechanical forces, stresses, strains, and velocities play a critical role in many important aspects of cell physiology, such as cell adhesion, motility, and signal transduction. The modeling of cell mechanics is a challenging task because of the interconnection of mechanical, electrical, and biochemical processes involvement of different structural cellular components and multiple timescales. It can involve nonlinear mechanics and thermodynamics, and because of its complexity, it is most hkely that it will require the use of computational techniques. Typical steps in the development of a cell modeling include constitutive relations describing the state or evolution of the cell or its components, mathematical solution or transformation of the corresponding equations and boundary conditions, and computational implementation of the model. 

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