Cardiac tissue engineering

Narmoneva, D., Zhang, S., Kamm, R.D., and Lee, R.T. Angiogenesis and Cardiac Tissue Engineering with Peptide Hydrogels and Related Compositions and Methods of Use Thereof, 2003-US14092 2003096972 (2003). 

Table 5 Work done on cardiac tissue engineering applications... 

Park H, Radisic M, Lim JO et al (2005) A novel composite scaffold for cardiac tissue engineering, hi Vitro Cell Dev Biol - Animal 41 188-196... 

Senel Ayaz, H.G., et al., 2014. Textile-templated electrospun anisotropic scaffolds for regenerative cardiac tissue engineering. Biomaterials 35, 8540—8552. 

I.C. Parrag, The Development of Elastomeric Biodegradable Polyurethane Scaffolds for Cardiac Tissue Engineering, Dissertation, The University of Toronoto, Toronto, ON, 2010. 

D. Kai, M.P. Prabhakaran, G. Jin, S. Ramakrishna, Guided orientation of cardiomyocytes on electrospun ahgned nanofibers for cardiac tissue engineering, J. Biomed. Mater. Res. B 98B (2011) 379-386. 

Motivated by the development of cardiac tissue engineering based on electrically active electrospun nanofibers, Fernandes and co-workers reported on the preparation of electrospun hyperbranched PLL nanofibers containing polyaniline in the form of nanotubes.Both electroactivity and biocompatibility demonstrated by the composite nanofibers opens the possibility of using this material as a scaffold in cardiac tissue engineering. 

Kai D., Prabhakaran M. R, Jin G., and Ramakrlshna S., Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering,/ Biomed. Mater. Res. A, 2011,99,3. 

The development of heart-on-a-chip platforms is one of the most challenging areas in the organ-on-a-chip research. The challenges are to mimic dynamic cardiac tissue microenvironments. It is difficult to simultaneously study the contractility and electrophysiological responses of cardiac tissues. Nevertheless, a few studies have been done with cardiac tissue engineering to mimic cardiac tissue microenvironments [51] and heart-on-a-chip platforms to study the contractility and electro-physiological response of cardiac tissue at the same time (Eig. 4 A-C) [52]. 

Control of the cellular microenvironment is critical for achieving myocardial regeneration. It is a well-known fact that the majority of cells injected into the myocardium do not smvive. Those that survive might not physiologically couple with the native myocardium. This makes the choice of scaffold critical for cardiac tissue engineering. The scaffolds are expected to support the cells as a three-dimensional structure that enables the development of localized extracellular matrix (ECM) and intercellular... 

Polyurethanes coculture systems for cardiac tissue engineering... 

Bofflto M, Sartori S, CiaideUi G. Polymeric scaffolds for cardiac tissue engineering requirements and fabrication technologies. PolymInt January 2014 63(1) 2-11. 

Cardiac tissue engineering/regenerative medicine future trends... 

Alperin, C., Zandstra, P.W., Woodhouse, K.A., 2005. Pol5mrethane films seeded with embryonic stem ceU-derived cardiomyocytes for use in cardiac tissue engineering applications. Biomaterials 26, 7377-7386. 

Baheiraei, N., Yeganeh, H., Ai, J., Gharibi, R., Azami, M., Faghihi, F., 2014. Synthesis, characterization and antioxidant activity of a novel electroactive and biodegradable polyurethane for cardiac tissue engineering application. Materials Science and Engineering C 44, 24—37. 

Chen, Q.Z., Harding, S.E., Ali, N.N., Lyon, A.R., Boccaccini, A.R., 2008a. Biomaterials in cardiac tissue engineering ten years of research survey. Materials Science and Engineering Reports 59, 1-37. 

Curtis, M.W, Russell, B., 2009. Cardiac tissue engineering. Journal of Cardiovascular Nursing 24, 87-92. 

GuiUemette, M.D., Park, H., Hsiao, J.C., Jain, S.R., Larson, B.L., Langer, R., Freed, L.E., 2010. Combined technologies for microfabricating elastomeric cardiac tissue engineering scaffolds. Macromolecular Bioscience 10, 1330-1337. 

Hidalgo-Bastida, L.A., Barry, J.J., Everitt, N.M., Rose, F.R., Buttery, L.D., Hall, I.P., Claycomb, W.C., Shakesheff, K.M., 2007. Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering. Acta Biomaterialia 3, 457 62. 

Kai, D., Prabhakaran, M.P., Jin, G., Ramakrishna, S., 2011a. Guided orientation of cardiomyo-cytes on electrospun aligned nanoflbers for cardiac tissue engineering. Journal of Biomedical Materials Research Part B Applied Biomaterials 98B, 379-386. 

Ravichandran, R., Venugopal, J.R., Sundarrajan, S., Mukheijee, S., Sridhar, R., Ramakrishna, S., 2013. Expression of cardiac proteins in neonatal cardiomyocytes on PGS/fibrinogen core/shell substrate for cardiac tissue engineering. International Journal of Cardiology 67,1461-1468. 

Senel-Ayaz, H.G., Perets, A., Ayaz, H., GUroy, K.D., Govindaraj, M., Brookstein, D., Lelkes, P.I., 2014. TextUe-templated electrospun anisotropic scaffolds for regenerative cardiac tissue engineering. Biomateiials 35, 8540-8552. 

Chen PH, Liao HC, Hsu SH, Chen RS, Wu MC, Yang YF, et al. A novel polyurethane/ cellulose fibrous scaffold for cardiac tissue engineering. RSCAdv 2015 5 6932-9. 

Parrag IC, Zandstra PW, Woodhouse KA. Fiber alignment and coculture with fibroblasts improves the differentiated phenotype of murine embryonic stem ceU-derived cardiomyo-cytes for cardiac tissue engineering. Biotechnol Bioeng 2012 109 813-22. 

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