Cell wall anchoring

Fernandez-Tornero, C., Lopez, R., Garcia, E., Gimenez-Gallego, G., and Romero, A. (2001). A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor LytA. Nat. Struct. Biol. 8, 1020-1024. 

The Gram-positive bacterium Streptococcus pneumoniae is an important cause of respiratory tract infections, bacteremia, and meningitis. In this strain, the cell wall anchored pneumococcal surface protein A (PspA) has been demonstrated to bind lactoferrin [181]. PspA and closely related proteins in a variety of pneumococcal isolates are most likely involved in the sequestration of iron from lactoferrins, and finally contribute to the virulence of these bacteria. However, the means by which the pneumococcus acquires iron at the mucosal surface during invasive infection is not well understood at the molecular level [182],... 

Taylor, J. M. and Heinrichs, D. E. (2002). Transferrin binding in Staphylococcus aureus involvement of a cell wall-anchored protein, Mol. Microbiol., 43, 1603-1614. 

Kant et al. 2011). Although the analysis did not reveal any potential niche specific genes, a larger secretome and greater number of LPXTG-cell wall anchor sortases were identified in probiotic strains than in dairy strains (Kant et al. 2011). Also, in a comparative analysis between secretomes from 26 LAB strains, the largest secretomes were typically found in probiotic or Gl-related strains (Zhou et al. 2010). This is not surprising, as probiotic strains are expected to secrete surface proteins for survival and interaction in the GI tract (Kleerebezem et al. 2010). 

Cortes-Perez, N.G., Azevedo, V., Alcocer-Gonzalez, J.M., et al. (2005) Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli. J Drug Targ 13, 89-98. 

Fig. 8.1 Model of cadaverine biosynthesis, its P22-mediated regulation, and its role in the cell wall-anchoring system in Selenomonas ruminantium. Refer to the text for details...

Abe, H., Shimma, T. I. Jigami, Y. (2003). In vitro oligosaccharide synthesis using intact yeast cells that display glycosyltransferases at the cell surface through cell wall-anchored... 

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