Cell shape change

Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol 2004 142 161-171. 

Barrett, K., Leptin, M., and Settleman, J. (1997). The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91, 905—915. 

Hacker, U., and Perrimon, N. (1998). DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12, 274-284. 

Malagoli, D, and Ottaviani, E. 2004. Yessotoxin affects fMLP-induced cell shape changes inMytilus galloprovincialis immunocytes. Cell Biol Int 2, 57-61. 

Bereiter-Halm J, Votli M (1994) Dynamics of mitochondi ia in living cells Shape changes, dislocations, fusion, and fission of mitochondria. Microsc Res Tech 27 198—219. 

The actin cytoskeleton is important in cell shape changes, polarization, motility, chemotaxis, metastasis and ceU division, and Rho family proteins play critical roles in these effects. The involvement of PLD in changes in the actin cytoskeleton was first suggested by the effects of exogenous PLD and PA, which induced actin stress fiber formation and also increased the F-actin content of fibroblasts [172, 173]. Another study utilizing endotheUal ceUs also showed that PA that was free of LPA induced actin stress fiber formation [174]. Furthermore, the effects of LPA to induce this change in the actin cytoskeleton and also PA formation were blocked by butan-l-ol, but not butan-2-ol [174] (Fig. 4.6). 

Costa, M, Wilson, E., and Wieschaus, E. (1994). A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 76 1075-1089. 

Leptin, M. and Grunewald, B. (1990). Cell shape changes during gastrulation in Drosophila. Development 770 73-84. 

Morize, P., Christiansen, A., Costa, M., Parks, S., and Wieschaus, E. (1998). Hyperactivation of the folded gastrulation pathway induces specific cell shape changes. Development 725 589-597. 

C. Tiruppathi, A.B. Malik, P.J. Delvecchio, C.R. Keese and I. Giaever, Electrical method for detection of endothelial-cell shape change in real-time -assessment of endothehal barrier function. Proceedings of the National Academy of Sciences of the United States of America, 89(17), 7919-7923 (1992). 

When REFs were exposed to the membrane-permeant PKA activator, 8-(4-chlorophenylthio)-cAMP (CPT-cAMP), they underwent the same morphological transformation as described above (disruption of actin stress fibers leading to cell shape changes). In contrast, cells microinjected with the caged peptide (5 pM estimated intracellular concentration) and exposed to UV irradiation were unable to respond to the CPT-cAMP stimulus, demonstrating that the CPT-cAMP activation of the PKA pathway had been efficiently blocked in vivo by the decaged peptide [152],... 

Malek, A.M., Izumo, S. Mechanism of endothelial cell shape change and C5doskelet-al remodeling in response to fluid shear stress. J. Cell Sci. 109(Pt 4), 713-726 (1996)... 

In the course of our phenotypic screening from a chemical library in NPDepo and microbial metabolites, we identified several hundreds of compounds that induced unique cell-shape changes in src -NRK and HeLa cells. Among them, NPD6689, NPD8617, and NPD8969 were very potent, as evidenced by the nanomolar ranges of their effective doses. 

Myat, M M Andrew, D. J. (2000b). Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands. Development 127,4217-4226. 

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