Cell Proliferation in Rodent Brain After Ischemia

While all of the above-mentioned studies were performed using adult models, the effects of focal ischemia on SVZ or SGZ precursor cells were also investigated in neonatal animals. Unilateral hypoxic-ischemic injury elicited an increase of BrdU+ cells in ipsilateral hippocampus, mainly DG, and the number of BrdU+ neuronal cells was also increased in DG, while the number of oligodendrocytes decreased (Bartley et al. 2005). Ischemia also upregulated progenitor cell proliferation in neonatal SVZ, peri-infarct striatum (Plane et al. 2004), and cortex (Fagel et al. 

However, a more severe insult had the opposite effect, reducing the ability of SVZ to generate progenitors (Levison et al. 2001). 

To date, over 100 papers have been published addressing the issue of postischemic neurogenesis, and the reader is referred to a number of recent reviews for further information and analysis on the topic (Sharp et al. 2002 Kokaia and Lindvall 2003 Felling and Levison 2003 Lindvall and Kokaia 2004 Abrahams et al. 2004 Zhang et al. 2005 Lichtenwalner and Parent 2006). 

Zola-Morgan et al. (1986) were the first to report a CA1 sector lesion in a patient who had suffered from a transient global ischemic insult during cardiac 

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Cell Proliferation in Rodent Brain After Ischemia... 

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