Cell adhesion-mediated drug resistance

EMT6 Murine Breast Cell adhesion-mediated drug resistance (CAM-DR) Seen in vivo, not in 2-D cultures (109)... 

As obvious from literature search, cell-cell contacts have been a focus of interest in cancer research for many years (Ruch and Trosko 2001 Trosko and Ruch 1998). Recently, the impact of cell-matrix interactions on tumor ceU resistance was evidently demonstrated in several ceU lines from different soUd and hematologic tumor entities in vitro. Dependent on the characteristics, the phenomena were caUed ceU adhesion-mediated radiation resistance (CAM-RR) or cell adhesion-mediated drug resistance (CAM-DR) (CoRDES and Meineke 2003 Dalton 2003 Dami-ANO et al. 1999). Most relevant for in vitro cancer research, this effect can easily be observed when comparing the radio- or chemosensitivity of cells plated on a conventional plastic culture dish with cells plated on different matrix proteins like fibronectin, coUagen, or laminin. The contact with ECM proteins and the altera-... 

Estrugo D, Fischer A, Hess F et al (2007) Ligand bound betal integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells. PLoS ONE 2 e269... 

Interactions between cancer cells and the extracellular matrix can affect their response to chemotherapy. The basic mechanisms involved in the so-called adhesion-mediated drug resistance are rather complex and still under investigation. Agents that can modulate cell adhesion might enhance the effects of chemotherapy (Tredan et al. 2007). 

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