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Ceftobiprole

Ceftobiprole Cephalosporin 2008 2009 2010 Nosocomial pneumonia and cSSSIs caused by MRSA... [Pg.352]

Cephalosporins p-Lactum Ceftobiprole Antibacterial Inhibits bacterial cell Phase III Basilea 740-744... [Pg.71]

Bush K, Heep M, Macielag MJ, Noel GJ. (2007) Anti-MRSA p-lactams in development, with a focus on ceftobiprole The first anti-MRSA p-lactam to demonstrate clinical efficacy. Expert Opin Invest Drugs 16 419 29. [Pg.177]

Yun HC, Ellis MW, Jorgensen JH. (2007) Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus Aureus isolates recently recovered from US military trainees. Diagn Microbiol Infect Dis 59 463-466. [Pg.177]

Widmer AF. (2008) Ceftobiprole A new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus Aureus. Clin Infect Dis 46 656-658. [Pg.177]

Noel GJ, Bush K, Bagchi P, lanus J, Strauss RS. (2008) A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin Infect Dis 46 647-655. [Pg.177]

The modified cephalosporin ceftobiprole (31-8), yet another compound that contains a double bond at the ring carbon, though in this case with a rather complex extended side chain, has shown activity in the clinic against some strains of multidrug resistant bacteria. The synthesis starts with the weU-precedented acylation of the cephalosporin (31-2), available in several steps from the commercially available 7-acetoxy cephalosporanic acid, with the activated thiadiazole carboxylic acid (31-1). The hydroxyl group in the product (31-3) is then oxidized with manganese dioxide to afford the corresponding aldehyde (31-4). This product is then condensed with the fcw-pyrrolidyl phosphonium salt (31-5), itself protected with the... [Pg.565]

Arofylline, 202 Cariporide, 57 Dronaderone, 140 Regadenoson, 197 Selodenoson, 196 Tecadenoson, 195 Antiasthmatic Atreluton, 90 Ciclesonide, 36 Cilomilast, 30 Roflumilast, 44 Antibacterial Amustaline, 218 Ceftobiprole, 213 Eitapenem, 214 Garfenoxacin, 176 Gatifloxacin, 174 Gemifloxacin, 210 Iclaprim, 125... [Pg.241]

Beta-lactams. Ceftobiprole shows promising activity against MRSA, and is in phase III clinical trials [369]... [Pg.1558]

Clinically important, potentially hazardous interactions with anticoagulants, ceftobiprole, cyclosporine, demeclocydine, doxycydine, gentamicin, imipenem/cilastatin, methotrexate, minocycline, oxytetracydine, tetracycline... [Pg.93]

Clinically important, potentially hazardous interactions with acenocoumarol, aspirin, bivalirudin, butabarbital, capsicum, ceftobiprole, dabigatran, danaparoid, desvenlafaxine, dong quai, ginger, horse chestnut (bark, flower, leaf, seed), palifermin, red clover, salicylates, tazobactum, tirofiban... [Pg.276]

Clinically important, potentially hazardous interactions with ceftobiprole... [Pg.450]

Eichenbaum G, Skibbe J, Parkinson A, Johnson MD, Baumgardner D, Ogilvie B, Usuki E, Tonelli F, Holsapple J, Schmitt-Hoffmann A (2012) Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs a case study example with the prodrug ceftobiprole medocaril. J Pharm Sci 101 1242-1252... [Pg.156]

See other pages where Ceftobiprole is mentioned: [Pg.584]    [Pg.604]    [Pg.566]    [Pg.993]    [Pg.281]    [Pg.14]    [Pg.323]    [Pg.324]    [Pg.326]    [Pg.250]    [Pg.1557]    [Pg.1558]    [Pg.106]    [Pg.638]    [Pg.642]    [Pg.625]    [Pg.626]    [Pg.211]    [Pg.130]   
See also in sourсe #XX -- [ Pg.352 ]

See also in sourсe #XX -- [ Pg.281 ]

See also in sourсe #XX -- [ Pg.213 ]



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Ceftobiprole medocaril

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