Cefpirome activity

Fourth-generation cephalosporins (cefepime and cefpirome) are active with respect to a broad spectrum of Gram-positive and Gram-negative aerobes. They have an unusually low affinity with beta-lactamase and the ability to quickly pass through the periplasmatic space. [Pg.443]

Fourth-generation cephalosporins were developed such as cefpirome and cefepime with additional activity against gram negative pathogens and greater stability against beta-lactamases. [Pg.410]

Aminothiazol methyloxime acetic acid 19 (ATMAA) is commercially available as is the proprietary activated form of ATMAA known as DAMA 20. ATMAA side chain and its close relations are critically important structural features of third- and fourth-generation commercially viable cephalosporin-based antibiotics related to cefovecin, such as cefetamet pivoxil, cefpodoxime proxetil, cefuroxime axetil, cefpirome, cefotiam hexetil, cefdinir, ceftbuten, ceftiofur, and cehxime (Scheme... [Pg.196]

Paradis, D. Vall4e, F. Allard, S. Bisson, C. Daviau, N. Drapeau, C. Auger, F. LeBel, M. Comparative study of pharmacokinetics and serum bactericidal activities of cefpirome, ceftazidime, ceftriaxone, imipenem, and ciprofloxacin. Aretimicro6.Agerafs Chemother., 1992, 36, 2085-2092... [Pg.297]

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