Cefazolin analysis

Byrn, S.R. Gray, G. Pfeiffer, R.R. Frye, J. Analysis of solid-state carbon-13 NMR spectra of polymorphs (benox-aprofen and nabilone) and pseudopolymorphs (cefazolin). J. Pharm. Sci. 1985, 74 (5), 565-568. 

A retrospective analysis of allergic reactions (drug-induced fever and rash) in 90 adults with cystic fibrosis, of whom 26 developed probable allergic reactions to parenteral beta-lactams. There was drug-induced fever in 54 and skin reactions in 28 of 897 treatment courses (6 and 3.1% respectively). There was one case of non-fatal anaphylaxis. The numbers of allergic reactions per number of patients receiving specific antibiotics were carbenicillin 4/56, mezlocillin 7/42, piperacillin 11/31, ticarcUlin 1/20, cefazolin 0/24, ceftazidime 1/35, imipenem + cilastatin 4/16, and nafcillin 3/36 (17). 

The use of antibiotic prophylaxis for percutaneous endoscopic gastrostomy (PEG) is controversial. Although postoperative peristomal infection can occur in up to 30% of patients, clinical trials with cefazolin given 30 minutes preoperatively in this population are conflicting. A pharmacoeconomic study using a meta-analysis of available studies to determine efficacy suggested that antibiotic prophylaxis cost was effective for patients undergoing PEG placements. ... 

Paap, C.M. Nahata, M.C. A novel micromethod for the simultaneous analysis of cefotaxime and desa-cetylcefotaxime from plasma using ion pair high performance liquid chromatography. J.Liq.Chromatogr., 1989, 12, 2385-2395 [plasma cefoxitin (IS) also acetaminophen, caffeine, cefazolin, methicillin, theophylline, vancomycin non-interfering ampicillin, gentamicin, ibuprofen, phenobarbital]... 

Parker, C.E. Perkins, J.R. Tomer, K.B. Shida, Y. O Heira, K. Nanoscale packed capillary liquid chromatography-electrospray ionization mass spectrometry analysis of penicillins and cephems. J.Chromatogr., 1993, 616, 45-57 [capillary HPLC electrospray LC-MS serum also ampicillin, car-benicUlin, cefalothin, cefazolin, cefmenoxime, cefmetetzole, cefoperazone, cefotaxime, cefotiam, cefoxitin, cephalexin, cloxacillin, dicloxacillin, penicillin G, pipericillin, sulbenicillin]... 

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