CEC evaluation

Meredith, T.J., Jacobsen, D., Haines, J.A., Berger, J-C. (1993). Antidotes for poisoning by cyanide. In IPCS/CEC Evaluation of Antidote Series, Vol. 2. Cambridge University Press. 

Tsang has prepared a series of publications on data required for modelling the combustion of methane [45], methanol [53], propane [54], isobutane [55] and propene [56]. The treatment is less detailed than in the case of the CEC publications there is less evaluation of the primary data, often previous evaluations are accepted, and there is no graphical presentation of results. However, data on more than 500 reactions are considered and, where there are no experimental data, estimates of the rate constants are given. Unimolecular reactions are also treated slightly differently from the CEC evaluations as described in Section 3.3. 

Specifically, a stoichiometric reaction mixture was studied at a pressure of 20 Torr and a residence time of 8 s. Both isothermal and non-isothermal models were considered for a range of temperatures between 500 and 2311 K. The third body M is assumed to be made up from the molecular species H2, O2 and H2O with relative efficiencies of 1 0.4 6, respectively, for all third-body reactions [105]. Although the chemistry is derived from the original Dougherty and Rabitz scheme, the rate data were updated and, where possible, obtained from the CEC evaluation tables [26]. The sources for other reaction rate data are shown in Table 4.3. Oscillating ignition reactions constitute a particularly stringent test of mechanism... 

During the CEC-seminar in Bad Zwischenahn, Kowalewsky (1) concluded that NH3 is suitable for use as a main component. He defined a main component as a compound whose concentration correlates with the sensory evaluation of odour intensity. 

Lord et al. analyzed a mixture of steroids by CEC-ESI/MS and interfaced externally tapered CEC columns in both sheathless and sheath-flow arrangement. Sensitivity was found 20-fold higher in the sheathless configuration. The same conclusion was drawn by Warriner et ah, who evaluated CEC-nanospray/MS vs. CEC-microspray/MS with an ion trap using five corticosteroids. Cahours et al. used CEC-ESI/MS for a drug metabolism study and obtained a simultaneous baseline separation of flunitrazepam and its major metabolites. For CEC-ESI/MS coupling, the commercially available packed-CEC column was connected... 

The limits of the electrochromatographic retention factor defined by Equation 6.54 are that both k and must be separately evaluated under specific experimental conditions used in CEC. These limitations can be avoided describing the retention of analytes in CEC by a peak locator that can be evaluated directly from the electrochromatogram as follows [256] ... 

The dichroic properties of the Li modiEed montmorillonite were followed by orientation of thin films (0-45°) in the IR beam (FTIR Brucker IFS 88). The cationic exchange capacity (CEC) of the samples calcined at 400°C was evaluated. 

After a period of consultation on its workability, REACH was published as a proposal for a regulation in October 2003 (CEC, 2003a). It was finally agreed by the European Parliament and the Council of Ministers in December 2006 (Regulation (EC) 1907/2006, Directive 2006/12/lEC) and came into force in June 2007. The components of REACH — registration, evaluation, authorization and restrictions — are outlined below. 

The use of antibiotic-based CSPs has been reported in capillary electrochromatography (CEC) for chiral resolution [60]. Teicoplanin CSP covalently bonded to silica gel was used to resolve the enantiomers of tryptophan and dinitrobenzoyl leucine by CEC [61]. Good levels of enantioselectivity were obtained with optimized separations. Vancomycin covalently bonded to silica gel was also evaluated in CEC for the chiral resolution of thalidomide and jS-adrenergic blocking agents under all the three mobile phase modes. The... 

Columns in CEC often have a packed and an open segment with a detection window in between. The conductivities of the open and packed segments, a open and gpacked, are then evaluated from the currents measured with the capillary tubing in the absence, iopen, and presence, ipacked, of the packing by using Eqs. 1.1 and 1.8 as... 

In recent work within our laboratories, we have evaluated a number of unbonded silicas by CEC specifically for the separation of a range of pharmaceutically relevant basic analytes and mixtures. We purposefully chose strong basic analytes that comprised a wide range of lipophilicities, molecular weights and log P values to robustly test the separation systems. The basic analyte test mixture contained two AstraZeneca R D compounds, benzylamine, nortriptyline, diphenhydramine and procainamide. 

Fields reported that continuous silica xerogels prepared from potassium silicate solutions could be used as highly permeable support media, and exhibit reasonable chromatographic efficiency in HPLC [23]. Minakuchi et al. reported the preparation and evaluation of continuous porous-silica columns that provide a much higher column efficiency in HPLC than do conventional columns packed with particles [13-16,18], The monolithic columns prepared in a capillary can also be used in CEC. 

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