CD4+Tcell

Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS Differential impact of mTOR inhibition on CD4+CD25+Foxp3+ regulatory T cells as compared to conventional CD4+ Tcells. Blood 2008 111 453-462. 

An analog of l,25(OH)2D3 (Ro 26-2198) in monotherapy significantly expanded the number of CD4+CD25+ Tcells in treated nonobese diabetic (NOD) mice and was effective in suppression of autoimmune diabetes [114]. Again, CD4+CD25+ T cells accumulated in the pancreatic lymph nodes. Such cells were able to inhibit the... 

Clear disease protection through l,25(OH)2D3 has been shown in the NOD mouse model of type I diabetes since vitamin D deficiency almost doubles the incidence of diabetes in female mice to 88% and induces diabetes in almost 50% of male mice. Diabetes was prevented by dietary administration of 50 ng of 1,25 (OH)2D3/day [135, 136]. A variety of additional studies in the NOD mouse model led to the l,25(OH)2D3-sensitive role of Thl-type Tcells and CD4+CD25+ Tregs (see... 

Newman LS and Kotzin BL (2000) Beryllium presentation to CD4-E Tcells underlies disease susceptibility HLA-DP alleles in chronic beryllium disease. Proc Natl Acad Sd USA 97 12717-12722. 

Memory CD4 and CD8 T cells can be divided in effector and central memory Tcells. Effector memory cells are thought to home to nonlymphoid tissues, whereas the central memory T cells localize more to secondary lymphoid tissue [29]. Although originally distinguished by the expression of CCR7 by the central memory T cells, it is clear that both subsets express CCR7 [29, 34]. However, it is thought that these memory cells can express every appropriate chemokine receptor [29]. 

N., Kamada, T, Imai, H., Goto, T, and Hibi, H. (2007) Exclusive increase of CX3CR1( + )CD28(-)CD4( -F) Tcells in inflammatory bowel disease and their recmitment as intraepithelial lymphocytes. Inflammatory Bowel Diseases, 13, 837-846. 

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