CB, receptor antagonists

Pyridine-, Phenyl-, Pyrimidine- and Pyrazole-based CB] Receptor Antagonists 295... 

IMIDAZOLE-, THIAZOLE-, PYRROLE- AND TRIAZOLE-BASED CB, RECEPTOR ANTAGONISTS... 

CB-, receptor antagonist, subnanomolar CB-, receptor ligand claimed to be analgesic (Makriannis and Deng, University... 

Recently, the CB, receptor was shown to couple the activated FGFreceptor to an axonal growth response via increased calcium influx into cerebellar granule neurons (Wilhams et al., 2003). CB, receptor antagonists inhibited the neurite outgrowth response stimulated by N-cadherin and FGF2. 

Jarbe, T.U.C., Andrzejewski, M.E. and DiPatrizio, N.V. (2002) Interactions between the CB] receptor agonist A -THC and the CB] receptor antagonist SR 141716 in rats open-field revisited, Pharmacol Biochem Behav, 73 911-919. 

Serra, S., Brunetti, G., Pani, M., Vacca, G., Carai, M.A., Gessa, G.L. and Colombo, G. (2002) Blockade by the cannabinoid CB, receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats, Eur J Pharmacol, 443 95-97. 

Tzavara, E.T, Davis, R.J., Perry, K.W., Li, X., Salhoff, C., Bymaster, F.P, Witkin, J.M. and Nomikos, G.G. (2003) The CB] receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex implications for therapeutic actions, Br JPharmacol, 138 544-53. 

Only CB, receptor antagonists counter the inhibitory effects of cannabinoids. 

Darmani, N.A. and Pandya, D.K. (2000) Involvement of other neurotransmitters in behaviors induced by the selective cannabinoid CB, receptor antagonist/inverse agonist in naive mice, J. Neural Trans. 107 931-945. 

The ability of cannabinoids to cause vascular effects implies that the vasculature contains a molecular target. Evidence to date suggests that there may be vascular cannabinoid receptors, which may either fall into the classical CBj/CBj classification or represent a new subtype. As stated above, the biphasic hypotension in response to anandamide is absent in CBi receptor knockout mice (Ledent et al., 1999). This clearly points to the involvement of the CBj receptor. However, it should be noted that this does not conclusively identify the cannabinoid receptors as being on the vascular smooth muscle or associated with neuronal tissue. The sensitivity of vasorelaxant responses to CB receptor antagonists has been controversial, with some studies indicating that the responses are... 

Enone may also serve as a substrate for preparing pyrazolines, which epoxy ketone has been used to make hydroxyl-pyrazolines. For instance, the enone-ester substrate was used to make diaryl dihydropyrazole-3-carboxamides as CB] receptor antagonists. ... 

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