Carrier gallium compounds

The tissue distribution of gallium radionuclides is affected by many factors, such as the extent of neoplasm [62], the presence of inflammatory processes [63], sex hormone status [64], age [65], lactation [66], radiotherapy and chemotherapy treatment [67,68], amount of carrier gallium administered [69,70], and administration of compounds which block plasma protein binding of gallium [62,71]. The mechanism of uptake of Ga in tumors and abscesses has not been definitely established. One proposed mechanism suggests that Ga-transferrin interacts with specific transferrin receptors on the tumor cell, where upon binding to the cell the Ga-transferrin complex... 

The most widely used technique for the separation of large quantities of radioactive material is that of solvent extraction. The principle of the method is that ideally the partition coefficient of a compound between two solvents does not depend on concentration in a given set of conditions. This was shown in an early paper of Graham and Sea-borg (35) who demonstrated that the partition coefficients of gallium and cobalt chlorides between ether and aqueous hydrochloric acid were the same for concentrations of lCTli molar (i. e. no added carrier) as for 1-6xl0 s molar. 

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