Carotid artery intima-media

Inverse association. + = Positive association. 0 = No association. CHD = coronary heart disease. CVD = cardiovascular disease. Ml = myocardial infarction. IMT = intima media thickness. CCA-IMT = common carotid artery intima media thickness. LDL = low-density lipoprotein. 

Discuss the effect of statins (e.g., pravastatin, lovastatin) on carotid artery intima media thickness. 

Cardiovascular Carotid artery intima media thickness and serum lipids have been measured in 44 children with epilepsy taking valproic acid and 40 healthy children. Although there was no difference in serum lipid profiles, the intima media of the common carotid artery was significantly thicker in those who took valproic acid [346. This finding has uncertain significance and may be due to epilepsy and not to the drug. 

Erdemir A, CuUu N, Yi U, Demirtioglu F, Kir M, Cakmakgi H, Unal N, Dirik E. Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid. Brain Dev 2009 31(10) 713-6. 

Metabolism A prospective study foxmd increased body mass index, plasma insulin level, leptin, neuropeptide Y, and fasting insulinrglucose ratio in children taking VPA at 6 and 12 months after initiation of therapy [182 ]. Plasma ghrelin and adiponectin levels, lipid profiles, and carotid artery intima media thickness did not change significantly at the end of 6 and 12 months. 

Tokgoz H, Aydin K, Oran B, Kiyid A. Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate. Childs Nerv Syst July 2012 28(7) 1049-53. 

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