Cardiovascular protein expression

Alpha-1 antitrypsin deficiency Cardiovascular diseases Familial hypercholesterolemia Many types using vaccine, toxin or endogenous regulatory protein expression strategies... 

The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) reduce serum cholesterol levels and cardiovascular morbidity and mortality. Statins inhibit cancer cell proliferation in in vivo tumor growth in animal models (Campbell et al. 2006 Kusama et al. 2002 Paragh et al. 2003 Sivaprasad et al. 2006). Moreover, they increased iNOS mRNA and protein expression in the human breast adenocarcinoma cell line (MCF-7). NO cytotoxicity and tumor cell cytotoxicity were inhibited by iNOS inhibitors (Kotamraju et al. 2007). Based on these data, statins which are well known as a class of hyperlipidemic blockbuster drugs and are routinely used for lowering serum cholesterol levels are potential cancer drugs for use as NO inducers. 

Okazaki, H., Ishizaka, N., Sakurai, T., Kurokawa, K.., Goto, K., Kumada, M. and Takuwa, Y., 1993, Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system, Bioc/jem. Biophys. Res. Comm. 190 1104-1109. 

ILip (-511) allele C has been associated with increased expression of IL-ip protein and with increased risk for cardiovascular events [7],... 

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