Cardiodepressant effect

Propranolol may increase procainamide plasma levels. Additive cholinergic effects may occur when procainamide is administered with other drugp with anticholinergic effects. There is the potential of additive cardiodepressant effects when procainamide is administered with lidocaine. When a beta blocker, such as Inderal, is administered with lidocaine, there is an increased risk of lidocaine toxicity. 

Like chloroquine, quinine binds with plasmodium DNA, thus interfering in the synthesis of nucleic acids and preventing its replication and transcription. Quinine also suppresses a large portion of the enzymatic system and therefore it is characterized as a general protoplasmid toxin. This fact agrees well with the action of quinine on membranes, its local anesthetizing and its cardiodepressive effects. 

S) Increased risk of renal toxicity Blockade of normal compensation for cardiodepressant effects (S)... 

A number of industrial chemicals have been linked to cardiotoxicity. Aldehydes and primary alcohols that can be metabolically oxidized to aldehydes have exhibited cardiodepressant effects. Acute exposure to ethanol has caused arrhythmia. Isopropyl alcohol (2-propanol), a widely used industrial chemical and personal care product, may cause cardiovascular depression and excessively rapid heartbeat. Some halogenated hydrocarbons, including chloroform, ethyl bromide, and trichlo-rofluoromethane, have been implicated in cardiovascular disorders, including arrhythmia. 

Barry YA, Labow RS, Keon WJ, et al. 1990. Atropine inhibition of the cardiodepressive effect of mono( 2-ethyl hexyl)phthalatc on human myocardium Toxicol Appl Pharmacol 106 48-52. 

Scholz H. Antiarrhythmischer und Kardiodepressive Wirkungen antiarrhythmischer Substanzen. [Anti-arrhyth-mic and cardiodepressive effects of anti-arrhythmia agents.] Z Kardiol 1988 77(Suppl 5) 113-19. 

Schlepper M. Cardiodepressive effects of antiarrhythmic drugs. Eur Heart J 1989 10(Suppl E) 73-80. 

Herzig S, Ruhnke L, Wulf H. Functional interaction between local anaesthetics and calcium antagonists in gui-neapig myocardium 1. Cardiodepressant effects in isolated organs. Br J Anaesth 1994 73(3) 357-63. 

Gottlieb SS, Weinberg M. Cardiodepressant effects of mexiletine in patients with severe left ventricular dysfunction. Eur Heart J 1992 13(l) 22-7. 

In 28 subjects given either sevoflurane -I- nitrous oxide or enflurane + nitrous oxide anesthesia, sevoflurane caused fewer cardiodepressant effects than enflurane (3). Nevertheless, in 10 healthy subjects atrial contraction and left ventricular diastolic function, including active relaxation, passive compliance, and elastic recoil were impaired by sevoflurane (1 MAC) (4). 

Isradipine also produces the typical peripheral vasodilation seen with other dihydropyridines, but because of its inhibitory effect on the SA node, little or no rise in heart rate is seen. This inhibitory effect does not extend to the cardiac myocytes, however, because no cardiodepressant effect is seen. Despite the negative chronotropic effect,... 

Cardiodepressant effects, such as bradycardia and decreased force of myocardial contraction. AV blockade and asystole may also be seen. The AV block may be reversed by IV atropine. However, asystolic effects are not reversible by catecholamines. 

The antimuscarinic effects of quinidine are much more pronounced than those of procainamide. Thus, the cardiodepressant effects of procainamide are not offset by an increase in... 

Quinidine blocks open sodium channels, which decreases the rate of repolarization in a dose-dependent manner. Thus, the cardiac tissue may still depolarize normally, and the propensity for cardiac failure is lessened. Amiodarone, conversely, blocks resting channels, preventing depolarization in a dose-dependent manner. This could prevent excitation, particularly if the drug is in excess, leading to cardiac failure. Thus, this drug has a more pronounced cardiodepressant effect, as compared to quinidine, and a smaller margin of safety. 

Committee on Safety of Medicines/Medicines Control Agency. Cardiodepressant effects of itraconazole. Current Problems (200 ) 27, 11. 

When dmg-induced vasodilation is present, a compensatory increase in heart rate is expected subsequent to a decrease in arterial blood pressure and may help confirm the presence of a drug-induced pharmacological effect. A decrease in arterial blood pressure combined with a decrease in heart rate is likely a consequence of a cardiodepressive effect with negative chronotropy or decreased myocardial contractility. 

Atropine may be helpful to combat the cardiodepressant effect of taxine, but must be given early in the course of the disease. 

The cardiodepressant effect of isoflurane has been found to be similar to that of clinically equipotent doses of halothane (30C). 

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