Cardiac researchers

Molecular Genetics Program, Victor Chang Cardiac Research Institute (VCCRI), Sydney, Australia and... 

We thank David I. K. Martin for ongoing support of this work. Research in the authors lab is supported by grants from the National Health and Medical Research Council, the Australian Research Council, the Sylvia Charles Viertel Charitable Foundation, and by the Victor Chang Cardiac Research Institute. 

Jonathan D. W. Clarke Department of Anatomy and Developmental Biology, University College, London, UK David L. Cockroft Eormerly Imperial Cancer Research Eund, Oxford, UK Peter D. Currie Muscle Development Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia Michael J. Depew Department of Craniofacial Development, King s College London, London, UK... 

The Jim Moran Heart and Vascular Research Institute at Holy Cross Hospital in Fort Lauderdale, Florida, conducts cardiac research in collaboration with private corporations, university medical centers, and other research institutes. 

When used at room temperature in the presence of an active platinum catalyst in an inert solvent, e.g., acetone or ethyl acetate, oxygen will oxidize nonhindered, saturated hydroxyl groups and exposed allylic alcohols. This reagent has found extensive use in sugar chemistry and is particularly suited for the selective oxidation of either 3a- or 3j -alcohols of steroids. Other hydroxyl groups on the steroid skeleton are much less sensitive to oxidation. As a result, this reaction has been used extensively in research on polyhydroxy cardiac-active principles, e.g., the cardenolides and bufadienolides, where the 3-hydroxyl group is easily oxidized without extensive oxidation or dehydration of other hydroxyl groups. The ordinarily difficult selective oxidation of the... 

The narrow therapeutic range of digitalis related cardiotonic agents has resulted in an extensive effort to identify compounds in other structural classes which will improve cardiac function. The discovery of the heterocyclic cardiotonic drug, amrinone, led to research on other heterocyclic compounds for that indication. The imidazopyridine, isomazole (57), is representa-... 

In general, for smokers with cardiac disease, the benefits of nicotine replacement therapy outweigh the potential risks. In a safety and efficacy study that included veterans with cardiac disease, smoking concurrently with the nicotine patch was not associated with an increase in adverse events (Joseph et al. 1996). Although bupropion SR is generally well tolerated by smokers, it has not been adequately studied in persons with cardiac disease, and definitive conclusions regarding its safety in this patient population cannot currently be made (Society for Research on Nicotine and Tobacco 2003). 

Thus, the virtual heart may be used to simulate cardiac pathologies, their effect on the ECG, and the consequences of drug administration. It can be seen that drug discovery and assessment will be among the first fields where in silico technologies could reform research and development in a whole industry. 

The first examples of a consecutive radical 5 -exo-/dig-5-exo-dig cyclization of 1,5-diynes have been accomplished by the same researchers [43]. These authors were able to show that their cycloisomerization procedure provides access to strained semicyclic, conjugated dienes with a functionalized dioxatriquinane framework which occurs in the aglycones of steroidal cardiac glycosides, such as isogenine (3-96) [44] and C-norcardanolide (3-97) (Scheme 3.24) [45]. 

Sandman CA, McCanne TR, Kaiser DN and Diamond B (1982). Heartrate and cardiac phase influences on visual perception. Journal of Comparative Physiological Research, 91, 189-202. 

The objectives of this research are to develop short-term in vitro fatigue test methodologies that will predict long-term in vivo performance of elastomers used in cardiac assistance and related devices and to evaluate the fatigue life of candidate materials for potential use in these applications. 

Furthermore, pH determination has been used in other clinical research, both alone and in combination with other measurements. This research includes studies into the relationship between extracellular and intracellular pH in an ischemic heart [6, 7], the pH of airway lining fluid in respiratory disease [8], the study of pH as a marker for pyloric stenosis [9], malnutrition in alkalotic peritoneal dialysis patients [10], pH modulation of heterosexual HIV transmission [11, 12], and wound prevention and treatment [13], In addition, pH changes due to blood acidosis have been used to trigger and pace the ventricular rate of an implanted cardiac pacemaker [14], Research using pH measurements... 

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