Cardiac arrhythmias drug-induced

Decreased Cardiac Output related to adverse drug reactions (drug-induced arrhythmias)... 

Napolitano, C., Schwartz, P.J., Brown, A.M., Ronchetti, E., Bianchi, L., Pinnavaia, A., Acquaro, G. and Priori, S.G. (2000) Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. Journal of Cardiovascular Electrophysiology, 11, 691-696. 

Scherer, C.R., Lerche, C., Decher, N., Dennis, A.T., Maier, P., Picker, E., Busch, A.E., Wollnik, B. and Steinmeyer, K. (2002) The antihistamine fexofenadine does not affect l(Kr) currents in a case report of drug-induced cardiac arrhythmia. British Journal of Pharmacology, 137, 892-900. 

Doig JC. Drug-induced cardiac arrhythmias. Incidence, prevention and management. Drug Saf 1997 17(4) 265-75. 

Proarrhythmic effects of antiarrhythmic drugs In the Cardiac Arrhythmia Suppression Trial (CAST) treatment with encainide and flecainide, two class IC antiarrhythmic agents, successfully prevented ventricular ectopic beats in patients who had myocardial infarction. However, continued therapy with either drug was associated with a two- to three-fold increase in death due to cardiac arrhythmias. Similar results were reported for moricizine. Increased death was probably due to drug-induced fatal arrhythmias triggered by recurrent myocardial ischemia. 

Ebert SN, Liu XK, Woosley RL. Female gender as a risk factor for drug-induced cardiac arrhythmias Evaluation of clinical and experimental evidence. J WomeiVs Health 1998 7 547-57. 

Women also have a higher risk of developing drug-induced cardiac arrhythmia (Ebert et al., 1998) and life-threatening torsades de points arrhythmia may occur with drugs such as antihistamines, antibiotics or antipsychotics, making it important that Cardiac QT studies be conducted in volunteers of both genders (Woolsey, 2005). 

A variety of large-scale SNP-based association studies, partly including haplotype data, have contributed to narrowing down and identifying the genes involved in Parkinson s disease [37], myocardial infarction susceptibility [38], drug-induced cardiac arrhythmia [39], and drug-induced morbidity [40]. 

The genesis of the disruption in the rhythm of the heart manifesting as arrhythmias can have its roots in the abnormal electrical events in the conducting fibers (i.e., Purkinje fibers), cardiac myocytes, and/or pacemaker cells. Drug-induced... 

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