Cardiac arrhythmias malignant

Succinylcholine-induced hyperkalemia may lead to cardiac arrhythmia and arrest when plasma reaches 7 and 10 mM, respectively. The drug also may precipitate a fulminant attack of malignant hyperthermia in susceptible individuals (not to be confused with neuroleptic malignant hyperpyrexia, which involves dopamine and the CNS). Treatment in either case consists of cooling the body and administering oxygen and dantrolene sodium (discussed later). 

Rare reactions include seizures and neuroleptic malignant syndrome, a potentially fatal syndrome characterized by hyperpyrexia, muscle rigidity, irregular pulse or BP, tachycardia, diaphoresis, and cardiac arrhythmias. 

Rituximab is used against malignant B lymphocytes that express the CD20 antigen. The mean serum half-life is S9.8 hours, with variability possibly reflecting the tumor burden. Adverse reactions include hypersensitivity or anaphylactic reactions, cardiac arrhythmias, nausea, fatigue, and urticaria. Fever and chills may occur during infusion. 

Clinical signs of toxicity most frequently seen include sedation, coma, seizures, extrapyramidal effects, and rarely hypotension and cardiac arrhythmias. Coma and seizures may develop rapidly following an exposure to loxapine. Cardiac effects include prolonged QRS, Q-T intervals, and mild hypotension however, the cardiac effects are less pronounced than those associated with tricyclic antidepressants. Anticholinergic effects, including dry mouth, blurred vision, and tachycardia, have been seen. Neuroleptic malignant syndrome has been reported after therapeutic use and acute intoxication. Hypokalemia has also been noted. 

Halothane 0.8% 2.3 1 HR directly, but sensitizes heart to catecholamines Hepatitis, malignant hyperthermia, cardiac arrhythmias... 

A 10-year-old child had status epilepticus controlled with a combination of valproate, oxcarbazepine, and 48 hours of propofol infusion in a dose of 5.5 mg/kg/ hour. After weaning from propofol, a classic ketogenic diet was instituted in an attempt to provide long-term control of the seizures. A day later status epilepticus recurred and propofol was restarted at a rate of 6-9 mg/ kg/hour to suppress seizure activity (the diet, valproate, and oxcarbazepine were also continued). Shortly thereafter, he developed the classical constellation of malignant ventricular arrhythmias, hyperlipidemia, rhabdomyolysis, lactic acidosis, and biventricular cardiac failure. He did not survive. 

Halothane has the highest blood/gas partition coefficient of the volatile anaesthetic agents and recovery from halothane anaesthesia is comparatively slow. It is pleasant to breathe and is second choice to sevoflurane for inhalational induction of anaesthesia. Halothane reduces cardiac output more than any of the other volatile anaesthetics. It sensitises the heart to the arrhythmic effects of catecholamines and hypercapnia arrhythmias are common, in particular atrioventricular dissociation, nodal rhythm and ventricular extrasystoles. Halothane can trigger malignant hyperthermia in those who are genetically predisposed (see p. 363). 

Halothane 1 i 1 0.8% 2.3 Sensitizes heart to catecholamines Malignant hyperthermia, j hepatitis, cardiac j arrhythmias ... 

Statins may lower mortality in heart failure patients independent of any effects on coronary artery disease. This has been shown through SCD-HeFT data. Statins can also reduce appropriate ICD discharge in few studies including MADIT II post hoc subanalysis (92,115). To date, no randomized controlled trial has evaluated the influence of statins on malignant ventricular arrhythmias or cardiac death independent of the effect on coronary artery disease. 

---