Carcinogens IRIS classification

EPA has assigned 1,3-DNB a weight-of-evidence carcinogenic classification of D, which indicates that 1,3-DNB is not classifiable as to human carcinogenicity (IRIS 1994). EPA has not assigned a weight-of-evidence carcinogenic classification for 1,3,5-TNB. 

Chromium(VI) RfD (oral) Oral cancer classification Carcinogenic risk from inhalation exposure Inhalation cancer classification 3x1 O 3 mg/kg/day D—not classified 1.2x1 O 2 pg/m3 A—known human carcinogen IRIS 2000b... 

In 1988, the Scientific Advisory Board for the EPA offered an opinion that the weight-of-evidence was on a C-B2 continuum (possible-probable human carcinogen). The cancer classification is currently under review by EPA (IRIS 1996). 

The EPA has determined that endrin is not classified as to its human carcinogenicity (Group D) because the available information is inadequate to allow the classification (IRIS 1995). No cancer classifications exist for the IARC (no adequate data) (IARC 1987). The National Toxicology Program (NIP) has assigned endrin the carcinogen code N (negative) (NTP 1995). 

STATE Regulations a. Air Carcinogenic classification Acceptable ambient air concentrations Group Dc IRIS 1998... 

IRIS is a toxicology data file that contains data in support of human health risk assessment. It is compiled by the US EPA and contains over 500 chemical records. IRIS data, focusing on hazard identification and dose-response assessment, are reviewed by work groups of EPA scientists and represents EPA consensus. Among the key data provided in IRIS are EPA carcinogen classifications, unit risks, slope factors, oral reference doses, and inhalation reference concentrations. 

This classification has not been verified by EPA s Carcinogenicity Risk Assessment Verification Endeavor (CRAVE) Workgroup, is not on IRIS, and is currently undergoing review by EPA. 

EPA RfC RfD Carcinogenicity classification—creosote No data No data B19 IRIS 2001... 

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