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Carcinogens genotoxic agents

Mirsalis JC, Butterworth BE. 1980. Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents an in vivo-in vitro assay for potential carcinogens and mutagens. Carcinogenesis 1 621-625. [Pg.174]

Unfortunately, there has been an uncritical acceptance of the notion that a positive result in a rodent bioassay automatically implies a carcinogenic risk for humans. While this may well be the case for genotoxic agents, for nongenotoxic substances there will be exceptions, especially if the proliferative response occurs only at high doses" (Cohen and Ellwein 1991, 903). [Pg.79]

Suspect human carcinogen and known genotoxic agent Arecoline. One of the alkaloids present in betel nuts, the chewing of which leads to oral cancer (79MH0507, 82MI10503)... [Pg.737]

Suspect human carcinogen and known genotoxic agent... [Pg.733]

Dietrich, D. R., and Swenberg, J. A. (1991). Preneoplastic lesions in rodent kidney induced spontaneously or by non genotoxic agents Predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutat Res 248, 239-260. [Pg.435]

Major Applications Fuel cells, detecting microorganisms, antibacterial agent, treatment of acute and chronic hepatitis, gynecopathy, cardiovascular diseases, cerebrovascular diseases Safety/Toxicity Bladder toxicity, carcinogenicity, genotoxicity," mutagenicity ... [Pg.134]

Stich, H.F., and Powrie, W.D., 1982, Plant phenolics as genotoxic agents and as modulators for the mutagenicity of other food components, "Carcinogens and Mutagens in the Environ-... [Pg.28]

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See also in sourсe #XX -- [ Pg.423 , Pg.424 , Pg.424 , Pg.425 ]



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GENOTOXIC

Genotoxic agent

Genotoxicity carcinogen

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