Carcinogenicity studies pharmacological activity

In 1970, Rice et al. studied a diverse range of 3-substituted 1,2,3,4-tetrahydrocarba-zole derivatives in a preliminary pharmacological screening for general stimulation, depression, and autonomic activity, and found that 3-carboethoxy-9-(3-dimethyl-aminopropyl)-l,2,3,4-tetrahydrocarbazole (461) exhibited growth inhibition at a concentration of 1 gg/mL in mammary carcinoma tissue (400). These studies were based on the carcinogenic activity observed for the bis-angular bis-benzocarbazoles reported by Buu-Hoi et al. (401). 

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